Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes
Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes
复制标题
DOI：
10.1084/jem.20060045
复制
发表时间：
2006-04-17
影响因子：
15.3
通讯作者：
Unanue, ER
中科院分区：
文献类型：
--
作者：
Carrero, JA;Calderon, B;Unanue, ER
实验医学杂志淋巴细胞缺陷的小鼠在早期先天免疫反应中比正常小鼠对单核细胞增生李斯特菌感染更具抵抗力。这一悖论仍未得到解决：淋巴细胞是消除免疫力所必需的，但它们在感染早期的存在不是一种资产，甚至可能是有害的。我们发现，淋巴细胞缺陷的小鼠，这表明有限的细胞凋亡在感染器官，在感染的前四天是耐药的，但变得敏感时，移植淋巴细胞。与来自I型干扰素受体缺陷（IFN-α β R-/-）小鼠的淋巴细胞（其细胞凋亡减少）的移植，即使当吞噬细胞为IFN-α β R+/+时，也不会增加对感染的易感性。先天免疫的衰减部分是由于感染的凋亡期后吞噬细胞产生的巨噬细胞因子白细胞介素10。因此，免疫缺陷小鼠相对于正常小鼠更具抵抗力，因为后者经历了淋巴细胞凋亡的阶段，这对先天免疫反应是有害的。这是一个细菌病原体在感染早期产生级联事件导致容许感染生态位的例子。
The Journal of Experimental Medicine Mice deficient in lymphocytes are more resistant than normal mice to Listeria monocytogenes infection during the early innate immune response. This paradox remains unresolved: lymphocytes are required for sterilizing immunity, but their presence during the early stage of the infection is not an asset and may even be detrimental. We found that lymphocyte-deficient mice, which showed limited apoptosis in infected organs, were resistant during the first four days of infection but became susceptible when engrafted with lymphocytes. Engraftment with lymphocytes from type I interferon receptor-deficient (IFN-alpha beta R-/-) mice, which had reduced apoptosis, did not confer increased susceptibility to infection, even when the phagocytes were IFN-alpha beta R+/+. The attenuation of innate immunity was due, in part, to the production of the antiinflammatory cytokine interleukin 10 by phagocytic cells after the apoptotic phase of the infection. Thus, immunodeficient mice were more resistant relative to normal mice because the latter went through a stage of lymphocyte apoptosis that was detrimental to the innate immune response. This is an example of a bacterial pathogen creating a cascade of events that leads to a permissive infective niche early during infection.