Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis.
Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis.
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DOI：
10.2147/ott.s52730
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发表时间：
2013
影响因子：
4
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Cheng Q;Yi B;Wang A;Jiang X
miRNAs（miRs）是参与mRNA转录后调控的短RNA分子。miR在肿瘤发病机制中的作用最近才成为研究的焦点。越来越清楚的是，miR是在癌症发生和发展过程中癌细胞中的凋亡、增殖、侵袭和转移的重要调节因子，从而进一步加深了我们对癌症的理解。本文综述了miRs在肿瘤干细胞（CSCs）、上皮-间质转化（EMT）和肿瘤微环境（TM）中的作用及其作为新的治疗靶点和生物标志物的可能性。
miRNAs (miRs) are short RNA molecules that are involved in the posttranscriptional regulation of mRNA. The roles of miRs in tumor pathogenesis have only recently become a focus of research. It is becoming increasingly clear that miRs are important regulators of apoptosis, proliferation, invasion, and metastasis in cancer cells during cancer genesis and progression, furthering our understanding of cancer. In the present review, we summarize and evaluate the recent advances in our understanding of the characteristics of miRs as well as their regulated functions in cancer stem cells (CSCs), the epithelial-mesenchymal transition (EMT), and the tumor microenvironment (TM), describing their roles in tumor pathogenesis and their possible use as new therapeutic targets and biomarkers.