Identification of spatiotemporal gait parameters and pressure-related characteristics in children with Angelman syndrome: A pilot study
Identification of spatiotemporal gait parameters and pressure-related characteristics in children with Angelman syndrome: A pilot study
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DOI：
10.1111/jar.12462
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发表时间：
2018-11-01
影响因子：
2.4
通讯作者：
Weeber, Edwin J.
中科院分区：
文献类型：
--
作者：
Grieco, Joseph C.;Gouelle, Arnaud;Weeber, Edwin J.
背景：Angelman综合征(AS)的临床表现包括智力障碍、发育迟缓和运动功能低下。发展治疗学的倡议意味着迫切需要找到准确测量运动能力的方法。方法6名6-9岁的AS儿童走在仪器化的人行道上，测量时空参数(STP)和压力中心(COP)。将这些结果与典型发育儿童(TD)进行比较：44例TD 6~9岁，20例TD 4~5岁。结果分析显示，与TD个体相比，所有STP和步态可变性指数都存在差异。当AS参与者与年轻的TD个体进行比较时，除步长外，STP是不同的。对COP通路的分析显示，AS患儿的COP通路缺乏一致性和有效性。结论我们可以描述AS患儿和TD患儿的功能差异。STP和COP的变异性是AS患者步态中最有价值的成分。
BackgroundAngelman syndrome (AS) leads to clinical manifestations that include intellectual impairments, developmental delay and poor motor function. Initiatives to develop therapeutics implie an urgent need to identify methods that accurately measure the motor abilities.MethodsSix children with AS (6 to 9 years old) walked on an instrumented walkway to get spatiotemporal parameters (STPs) and center of pressure (CoP). These outcomes were compared to typically developing children (TD): 44 TD 6 to 9years old and 20 TD 4 to 5years old.ResultsAnalysis revealed differences in all STPs and gait variability index when compared to TD individuals. When AS participants were compared to younger TD individuals, except step length, STPs were different. Analysis of the CoP pathway revealed a less consistent and efficient pathway in AS.ConclusionsWe could delineate the functional difference between children with AS and TD children. The variability of STP and the CoP were the most valuable components in gait to be considered in AS.