The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease.
The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease.
复制标题
DOI：
10.3390/ijms21186740
复制
发表时间：
2020-09-14
影响因子：
5.6
通讯作者：
Toczek M
中科院分区：
文献类型：
--
作者：
Kicman A;Toczek M
大麻二酚（CBD）是大麻的一种非中毒性和通常耐受性良好的成分，在包括心血管疾病在内的各种疾病中表现出潜在的有益特性。由于其复杂的作用机制，CBD可能以不同的方式影响心血管系统。因此，我们回顾了CBD对健康和疾病的影响，以确定CBD用于医疗和健康目的期间心血管副作用的潜在风险，并阐明其在心血管疾病中的治疗潜力。对健康志愿者或动物施用CBD通常不会显著影响血流动力学参数。虽然CBD已被发现在高血压中表现出血管扩张和抗氧化特性，但它并没有影响高血压动物的血压。CBD的降压作用主要在应激条件下显示。CBD的许多积极作用已在心脏病（心肌梗塞、心肌病、心肌炎）、中风、新生儿缺氧缺血性脑病、脓毒症相关脑炎、糖尿病的心血管并发症以及肝脏和肾脏的缺血/再灌注损伤的实验模型中观察到。在这些病理条件下，CBD减少器官损伤和功能障碍，氧化和硝化应激，炎症过程和细胞凋亡等。然而，需要进一步的临床研究来推荐使用CBD治疗心血管疾病。
Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis which exhibits potential beneficial properties in a wide range of diseases, including cardiovascular disorders. Due to its complex mechanism of action, CBD may affect the cardiovascular system in different ways. Thus, we reviewed the influence of CBD on this system in health and disease to determine the potential risk of cardiovascular side effects during CBD use for medical and wellness purposes and to elucidate its therapeutic potential in cardiovascular diseases. Administration of CBD to healthy volunteers or animals usually does not markedly affect hemodynamic parameters. Although CBD has been found to exhibit vasodilatory and antioxidant properties in hypertension, it has not affected blood pressure in hypertensive animals. Hypotensive action of CBD has been mainly revealed under stress conditions. Many positive effects of CBD have been observed in experimental models of heart diseases (myocardial infarction, cardiomyopathy, myocarditis), stroke, neonatal hypoxic ischemic encephalopathy, sepsis-related encephalitis, cardiovascular complications of diabetes, and ischemia/reperfusion injures of liver and kidneys. In these pathological conditions CBD decreased organ damage and dysfunction, oxidative and nitrative stress, inflammatory processes and apoptosis, among others. Nevertheless, further clinical research is needed to recommend the use of CBD in the treatment of cardiovascular diseases.
登录
查看更多内容
影响因子：
2.2
作者：
CONSROE, P;SANDYK, R;SNIDER, SR
通讯作者：
SNIDER, SR
影响因子：
3.6
作者：
Alvarez, Francisco J.;Lafuente, Hector;Martinez-Orgado, Jose
通讯作者：
Martinez-Orgado, Jose
影响因子：
3.6
作者：
Arruza, Luis;Ruth Pazos, Maria;Martinez-Orgado, Jose
通讯作者：
Martinez-Orgado, Jose
影响因子：
--
作者：
Bhattacharyya, Sagnik;Fusar-Poli, Paolo;McGuire, Philip
通讯作者：
McGuire, Philip
影响因子：
15
作者：
Adams, R;Hunt, M;Clark, JH
通讯作者：
Clark, JH