Bioactive Iridoid Glycosides from the Whole Plants of Rehmannia chingii
Bioactive Iridoid Glycosides from the Whole Plants of Rehmannia chingii
复制标题
地黄全草中的生物活性环烯醚萜苷
DOI：
10.1021/acs.jnatprod.5b01126
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发表时间：
2016-02-01
影响因子：
5.1
通讯作者：
Yu, De-Quan
中科院分区：
文献类型：
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作者：
Liu, Yan-Fei;Shi, Guo-Ru;Yu, De-Quan
从生黄全株中分离得到9个新的环烯醚萜苷类化合物rehmachingiiosides A-I（1-9）和16个已知的类似物。化合物1 ~ 9的结构通过光谱分析和化学证据得到了明确。此外，在两次体外实验中，化合物5和10对lps诱导的NO产生有抑制作用，IC50值分别为2.5和7.3 μ M，化合物4、6和10-12（在10 μ M时评估）显示出对apap诱导的HepG2细胞损伤的肝保护作用。
Nine new iridoid glycosides, rehmachingiiosides A-I (1-9), together with 16 known analogues, were isolated from the whole plants of Rehmannia chingii. The structures of compounds 1-9 were elucidated on the basis of spectroscopic data analysis and from chemical evidence. Furthermore, in two vitro assays, compounds 5 and 10 showed an inhibitory effect on LPS-induced NO production with IC50 values of 2.5 and 7.3 mu M, and compounds 4, 6, and 10-12 (when evaluated at 10 mu M) exhibited evidence of hepatoprotective effects against APAP-induced HepG2 cell damage.