STAUROSPORINE, K-252 AND UCN-01 - POTENT BUT NONSPECIFIC INHIBITORS OF PROTEIN-KINASES
STAUROSPORINE, K-252 AND UCN-01 - POTENT BUT NONSPECIFIC INHIBITORS OF PROTEIN-KINASES
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DOI：
10.1016/0165-6147(89)90263-0
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发表时间：
1989-06-01
影响因子：
13.8
通讯作者：
BURGESS, GM
中科院分区：
文献类型：
--
作者：
RUEGG, UT;BURGESS, GM
(参考文献)1)，该化合物已被广泛用于研究蛋白激酶C的调节作用。然而，现在清楚的是，星状孢子素不仅阻断蛋白激酶C，而且还阻断其他各种蛋白激酶，使其分子靶点难以确定。
(Ref. 1), this compound has been used widely to investigate the regulatory role of protein kinase C. However, it is now clear that staurosporine blocks not only protein kinase C but also a variety of other protein kinases, making its molecular targets hard to define.