Relationship of plasma oxytocin levels to baseline symptoms and symptom changes during three weeks of daily oxytocin administration in people with schizophrenia.
Relationship of plasma oxytocin levels to baseline symptoms and symptom changes during three weeks of daily oxytocin administration in people with schizophrenia.
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DOI：
10.1016/j.schres.2016.02.014
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发表时间：
2016-04
影响因子：
4.5
通讯作者：
Kelly DL
中科院分区：
文献类型：
--
作者：
Lee MR;Wehring HJ;McMahon RP;Liu F;Linthicum J;Verbalis JG;Buchanan RW;Strauss GP;Rubin LH;Kelly DL
多项临床研究发现，精神分裂症患者的临床症状与外周催产素 (OT) 水平呈负相关。由于催产素是精神分裂症的公认治疗方法，因此重复服用 OT 对 OT 水平、临床症状的影响以及两者之间的关系令人感兴趣。在一项随机、双盲、平行组 3 周研究 (N=28) 中，每日给予鼻内 OT（20 IU，每日两次）或安慰剂 (PBO)，我们检查了 OT 给药对精神分裂症患者外周 OT 水平变化与临床症状变化之间相关性的影响。基线时，治疗组的 OT 水平没有显着差异。基线 OT 水平与任何症状测量之间没有显着关联。 OT/PBO 给药 3 周后，两个治疗组之间 OT 水平的变化幅度没有显着差异。治疗组之间外周 OT 水平变化与 BPRS 总评分和阴性症状评分变化之间的相关性没有差异。需要更大规模的研究来检验外源性 OT 对外周 OT 水平的影响以及后者与临床症状之间的关系。临床试验.gov = NCT00884897
Several clinical studies have found an inverse relationship between clinical symptoms and peripheral oxytocin (OT) levels in people with schizophrenia. As oxytocin is a putative treatment for schizophrenia, the effect of repeated dosing of OT on OT levels, clinical symptoms and the relationship between the two is of interest. In a, randomized, double blind, parallel group 3 week study(N=28) with daily administration of intranasal OT (20 IU twice daily) or placebo (PBO), we examined the effect of OT administration on the correlation between the change in peripheral OT levels and change in clinical symptoms in patients with schizophrenia. At baseline, there were no significant treatment group differences in OT levels. There were no significant associations between baseline OT levels and any symptom measures. After 3 weeks of OT/PBO dosing, there was no significant difference in the magnitude of change in OT levels between the two treatment groups. Correlations between changes in peripheral OT levels and changes in the BPRS total and negative symptom scores were not different between treatment groups. Larger studies are needed to examine the effect of exogenous OT on peripheral OT levels and the relationship between the latter and clinical symptoms. Clinical Trials.gov = NCT00884897