Age-related neural activity during allocentric spatial memory
Age-related neural activity during allocentric spatial memory
复制标题
DOI：
10.1080/09658210802077348
复制
发表时间：
2009-01-01
期刊：
影响因子：
2.1
通讯作者：
Morris, R. G.
中科院分区：
文献类型：
--
作者：
Antonova, E.;Parslow, D.;Morris, R. G.
在所有物种中，都可以看到与视觉无关的空间记忆的下降。我们采用虚拟现实模拟的莫里斯水迷宫，研究健康老龄化的影响，在allocentric空间记忆功能磁共振成像。基于体素的形态测定法用于确定海马体积的完整性。一个广泛的神经网络，包括额叶，顶叶，枕叶，丘脑和小脑区域被激活的年轻人和老年人，但只有年轻人显着激活双侧海马和左侧海马旁，以及右额极和背外侧前额叶皮层（DLPFC）在编码和右DLPC在检索。老年人海马灰质体积不变，然而，前额和海马旁功能衰减伴随着体积减少。我们的结论是，随着年龄的增长，在allocentric空间记忆的下降与衰减海马功能，以及受损的功能和结构的前额叶和海马旁区。
Age-related decline in allocentric (viewer-independent) spatial memory is seen across species. We employed a virtual reality analogue of the Morris Water Maze to study the effect of healthy ageing on neural activity during allocentric spatial memory using functional magnetic resonance imaging. Voxel-based morphometry was used to ascertain hippocampal volumetric integrity. A widespread neural network comprising frontal, parietal, occipital, thalamic, and cerebellar regions was activated in young and older adults, but only young adults significantly activated bilateral hippocampus and left parahippocampus, as well as right frontal pole and dorso-lateral prefrontal cortex (DLPFC) during encoding and right DLPC during retrieval. Hippocampal grey matter volume was unchanged in older adults; however, prefrontal and parahippocampal functional attenuation was accompanied by volumetric reduction. We conclude that the decline in allocentric spatial memory with age is associated with attenuated hippocampal function, as well as compromised function and structure of prefrontal and parahippocampal regions.