Vesicoureteric reflux and renal scars in asymptomatic siblings of children with reflux.
Vesicoureteric reflux and renal scars in asymptomatic siblings of children with reflux.
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反流儿童无症状兄弟姐妹的膀胱输尿管反流和肾脏疤痕。
DOI：
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发表时间：
1992
影响因子：
5.2
通讯作者：
J. Fettich
中科院分区：
文献类型：
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作者：
R. Kenda;J. Fettich
本研究的目的是确定膀胱输尿管反流(VUR)、肾疤痕和高血压在无症状的VUR儿童同胞中的发生率。这项研究包括105名VUR患者的兄弟姐妹。年龄4个月至6.3岁。所有患者均进行了直接放射性核素排尿膀胱术(DRVC)，其中47例(45%)检出输尿管返流。出生第一年高级别输尿管返流的发生率为50%，而2岁以上的兄弟姐妹的发生率为9%，而27名低级别输尿管返流的兄弟姐妹中，只有一人小于1岁。在47例VUR的同胞中，43例进行了99mTC-DMSA扫描，发现10例有肾脏瘢痕，占VUR同胞扫描的23%，占所有研究同胞的10%。一名儿童患有高血压。在无症状的同胞中识别VUR可能会预防肾损害及其后果。因此，仅有阳性家族史在确定VUR方面的预测价值为45%，而23%的兄弟姐妹有肾疤痕。这一发生率证明了对无症状同胞的常规调查是合理的，在早期阶段使用DRVC。
The purpose of the study was to determine the incidence of vesicoureteric reflux (VUR), renal scars and hypertension in asymptomatic siblings of children with VUR. The study comprised 105 siblings of patients with VUR. Their age ranged from 4 months to 6.3 years. All had a direct radionuclide voiding cystography (DRVC) performed, and VUR was detected in 47 of 105 (45%). High grade VUR in the first year of life had an incidence of 50% compared with a 9% incidence in siblings older than 2 years, while only one of the 27 siblings with a low VUR grade was younger than 1 year. In 43 of 47 siblings with VUR, a technetium-99m dimercaptosuccinic acid (99mTc-DMSA) scan was performed and renal scars were found in 10, which presents 23% of siblings with VUR who were scanned and 10% of all siblings studied. One child had hypertension. Identifying VUR among asymptomatic siblings could possibly prevent renal damage and its consequences. Thus, the predictive value of positive family history alone in identifying VUR was 45% while 23% of siblings had renal scars. This incidence justifies the routine investigation of asymptomatic siblings, by using DRVC at an early stage.
灵长类动物的膀胱输尿管反流。
影响因子：
8
作者：
Roberts,JA;Kaack,MB;Morvant,AB
通讯作者：
Morvant,AB