Bioequivalence of docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food
Bioequivalence of docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food
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DOI：
10.1007/s11745-007-3098-5
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发表时间：
2007-11-01
期刊：
影响因子：
1.9
通讯作者：
McCarthy, Deanna
中科院分区：
文献类型：
--
作者：
Arterburn, Linda M.;Oken, Harry A.;McCarthy, Deanna
二十二碳六烯酸（DHA）是一种长链ω-3脂肪酸，对眼睛和大脑发育以及持续的视觉，认知和心血管健康非常重要。与鱼类来源的油不同，来自植物来源（藻类）油的DHA的生物利用度尚未得到正式评估。我们评估了来自两种不同藻类菌株的胶囊中DHA油的生物等效性与来自藻类DHA强化食品的生物利用度。我们的28天随机、安慰剂对照、平行组研究比较了（a）两种不同的藻DHA油胶囊（“DHASCO-T”和“DHASCO-S”）的生物利用度，剂量为每天200、600和1,000 mg DHA（每组n = 12），以及（B）藻DHA强化食品（n = 12）。生物等效性基于血浆磷脂和红细胞DHA水平的变化。还测定了对花生四烯酸（ARA）、二十二碳五烯酸-n-6（DPAn-6）和二十碳五烯酸（EPA）的影响。DHASCO-T和DHASCO-S胶囊在血浆磷脂和红细胞中产生相同的DHA水平。DHA反应在剂量范围内呈剂量依赖性和线性，在200、600和1,000 mg剂量下，血浆磷脂DHA分别增加1.17、2.28和3.03 g/100 g脂肪酸。用DHASCO-S油强化的零食棒也在DHA剂量的基础上提供了等量的DHA。不良事件监测显示了极好的安全性和耐受性特征。两种不同的海藻油胶囊补充剂和一种海藻油强化食品代表了生物等效和安全的DHA来源。
Docosahexaenoic acid (DHA), a long-chain omega-3 fatty acid, is important for eye and brain development and ongoing visual, cognitive, and cardiovascular health. Unlike fish-sourced oils, the bioavailability of DHA from vegetarian-sourced (algal) oils has not been formally assessed. We assessed bioequivalence of DHA oils in capsules from two different algal strains versus bioavailability from an algal-DHA-fortified food. Our 28-day randomized, placebo-controlled, parallel group study compared bioavailability of (a) two different algal DHA oils in capsules ("DHASCO-T" and "DHASCO-S") at doses of 200, 600, and 1,000 mg DHA per day (n = 12 per group) and of (b) an algal-DHA-fortified food (n = 12). Bioequivalence was based on changes in plasma phospholipid and erythrocyte DHA levels. Effects on arachidonic acid (ARA), docosapentaenoic acid-n-6 (DPAn-6), and eicosapentaenoic acid (EPA) were also determined. Both DHASCO-T and DHASCO-S capsules produced equivalent DHA levels in plasma phospholipids and erythrocytes. DHA response was dose-dependent and linear over the dose range, plasma phospholipid DHA increased by 1.17, 2.28 and 3.03 g per 100 g fatty acid at 200, 600, and 1,000 mg dose, respectively. Snack bars fortified with DHASCO-S oil also delivered equivalent amounts of DHA on a DHA dose basis. Adverse event monitoring revealed an excellent safety and tolerability profile. Two different algal oil capsule supplements and an algal oil-fortified food represent bioequivalent and safe sources of DHA.