Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man
Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man
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P物质-包括人类在内的各种哺乳动物下呼吸道中的免疫反应性感觉神经
DOI：
10.1007/bf00217848
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发表时间：
2004
影响因子：
3.6
通讯作者：
C. Cuello
中科院分区：
文献类型：
--
作者：
Johan Lundberg;Tomas Hökfelt;C. Martling;Alois Saria;C. Cuello
用免疫组织化学方法研究了豚鼠、大鼠、猫和人下呼吸道内P物质(SP)免疫反应(IR)神经的分布和来源。此外，还对来自人体材料的活检标本进行了放射免疫分析。SP-IR神经主要分布在4个部位：1)衬里上皮下或内，2)血管周围，3)支气管平滑肌层内，4)局部气管-支气管神经节细胞周围。结合辣椒素处理的结扎实验表明，呼吸道内所有的SP-IR神经都是感觉神经。气管似乎主要由迷走神经供应，而肺内支气管和血管接受迷走神经和非迷走神经(脊髓)的SP-IR神经。人支气管内也有SP-IR神经，其定位与豚鼠基本相似。人气管和外周支气管中SP-IR的含量约为3-4pmol/g，与豚鼠相应组织的含量在同一范围内。总之，实验动物和人下呼吸道SP-IR神经的实验结果支持SP在迷走神经和非迷走神经(脊髓)控制支气管平滑肌张力和血管通透性中的重要性的功能证据。
SummaryThe occurrence and origin of substance P (SP)-immunoreactive (IR) nerves in the lower respiratory tract was studied by means of immunohistochemistry in the guinea-pig, rat, cat and man. In addition, biopsies from human material were also analysed by radioimmunoassay. SP-IR nerves were seen in four principal locations: 1) under or within the lining epithelium, 2) around blood vessels, 3) within the bronchial smooth muscle layer, and 4) around local tracheobronchial ganglion cells. Ligation experiments combined with capsaicin pretreatments indicated that all SP-IR nerves in the respiratory tract are sensory. The trachea seems to be mainly supplied by the vagal nerves, while intrapulmonary bronchi and blood vessels receive SP-IR nerves of both vagal and non-vagal (spinal) origin. SP-IR nerves were also found in the human bronchi with principally similar location as in the guinea-pig. The levels of SP-IR in the trachea and peripheral bronchi of man were about 3–4 pmol/g, which is in the same range as the content of corresponding tissues from the guinea-pig.In conclusion, the present experimental findings of SP-IR nerves in the lower respiratory tract in both experimental animals and man support the functional evidence for the importance of SP in the vagal and non-vagal (spinal) control of bronchial smooth muscle tone and vascular permeability.