Depression persistence and serotonin transporter genotype in adolescents under usual care conditions.
Depression persistence and serotonin transporter genotype in adolescents under usual care conditions.
复制标题
常规护理条件下青少年的抑郁持续性和血清素转运蛋白基因型。
DOI：
10.1089/cap.2011.0137
复制
发表时间：
2013
影响因子：
1.9
通讯作者：
Richardson,LauraP
中科院分区：
文献类型：
--
作者：
Kohen,Ruth;Myaing,MonT;Richards,Julie;Zhou,Chuan;McCauley,ElizabethA;Katon,Wayne;Richardson,LauraP
Objectives:Polymorphisms of the serotonin transporter (SERT) gene have been shown to influence the risk for depression. The goal of this study was to investigate a possible effect of SERT polymorphisms on severity and course of depression symptoms in a community sample of adolescents.Methods:Community-dwelling adolescents (n=192) ages 13–17 years, who were at risk for depression, were followed for a period of 6 months. Subjects donated a saliva sample for genotyping of the 5-HTTLPR and STin2 VNTR polymorphisms of SERT.Results:We found no associations between SERT genotype and severity of depressive symptoms at baseline. Depression symptom severity markedly decreased over time. For 5-HTTLPR, we observed a significant interaction between time and genotype, indicating the possibility that heterozygote genotype carriers (s/l) might experience a greater reduction in depression symptoms over time compared with adolescents with the 5-HTTLPR l/l genotype.Conclusions:Our study shows that for most community-dwelling adolescents, depressive symptoms decrease over time. A possible interaction effect of time and SERT genotype will require confirmation in larger studies.
