Pulmonary and disseminated infection due to Mycobacterium kansasii: a decade of experience.
Pulmonary and disseminated infection due to Mycobacterium kansasii: a decade of experience.
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堪萨斯分枝杆菌引起的肺部和播散性感染：十年的经验。
DOI：
10.1093/clinids/12.5.760
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Richard L. Harris
中科院分区：
文献类型：
--
作者：
Mark Lillo;Silva Orengo;P. Cernoch;Richard L. Harris
从1975年到1985年，在德克萨斯州的一家大型医院发现了55例分离的堪萨斯分枝杆菌患者（47例肺分离，8例弥散性分离）。患者平均年龄60岁，男性稍占优势。分离的堪萨斯分枝杆菌通常代表疾病。绝大多数因堪萨斯分枝杆菌引起肺部感染的患者有潜在的肺部疾病，70%有非肺部易感因素。堪萨斯分枝杆菌肺病的临床和影像学表现与肺结核相似。弥散性堪萨斯分枝杆菌感染发生在严重免疫功能低下的患者中，这些患者通常也有肺部易感性。弥散性感染通常累及肺、网状内皮系统、骨、关节和皮肤，并表现出与这些器官相关的体征和症状。尽管堪萨斯分枝杆菌对常规抗结核药物只有中等的体外敏感性，但大多数患者对含有利福平的方案有反应。堪萨斯分枝杆菌病患者的预后主要由其基础疾病决定。
Fifty-five patients with Mycobacterium kansasii isolates (47 pulmonary and eight disseminated) were identified at a large Texas hospital from 1975 to 1985. The mean age of patients was 60 years, and there was a slight male predominance. Isolation of M. kansasii usually represented disease. The great majority of patients with pulmonary infection due to M. kansasii had underlying pulmonary diseases, and 70% had nonpulmonary predisposing factors. M. kansasii pulmonary disease clinically and radiographically resembled pulmonary tuberculosis. Disseminated M. kansasii infection occurred in severely immunocompromised patients, who frequently had pulmonary predispositions as well. Disseminated infection most of ten involved the lung, reticuloendothelial system, bone, joint, and skin and presented with signs and symptoms related to these organs. Despite only moderate in vitro susceptibility of M. kansasii to routine antituberculous drugs, most patients responded to rifampin-containing regimens. The prognosis of patients with M. kansasii disease was determined primarily by their underlying diseases.