Blood pressure and human genetic variation in the general population.
Blood pressure and human genetic variation in the general population.
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DOI：
10.1097/hco.0b013e3283383e2c
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发表时间：
2010-05
影响因子：
2.3
通讯作者：
Newton-Cheh C
中科院分区：
文献类型：
--
作者：
Arora P;Newton-Cheh C
Hypertension is a complex trait with multiple environmental and genetic contributors. Linkage studies of rare Mendelian disorders of hypertension and hypotension have produced the most notable progress toward understanding the heritable basis of blood pressure. Association studies to identify common variants have been limited in the past by small sample sizes and most findings lack replication. Recently, well-powered, targeted candidate gene and genome-wide association studies have reported reproducible associations between common genetic variants and blood pressure. Identification of novel blood pressure genes will lead to an improved understanding of blood pressure regulation and the potential for novel therapies.
