Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering.
Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering.
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DOI：
10.1016/j.nano.2014.05.013
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Lo KW
中科院分区：
文献类型：
--
作者：
Carbone EJ;Jiang T;Nelson C;Henry N;Lo KW
利用生物活性小分子与先进材料相结合的肌肉骨骼再生工程方法已成为一种非常有前途的肌肉骨骼修复和再生策略。先进的生物材料技术已经揭示了用于肌肉骨骼组织工程的基于纳米纤维的支架作为小分子药物受控递送的载体。这篇综述文章重点介绍了最近的进展，在纳米纤维为基础的交付小分子肌肉骨骼再生工程。文章最后展望了挑战和未来的方向。
Musculoskeletal regenerative engineering approach using small bioactive molecules in conjunction with advanced materials has emerged as a highly promising strategy for musculoskeletal repair and regeneration. Advanced biomaterials technologies have revealed nanofiber-based scaffolds for musculoskeletal tissue engineering as vehicles for the controlled delivery of small molecule drugs. This review article highlights recent advances in nanofiber-based delivery of small molecules for musculoskeletal regenerative engineering. The article concludes with perspectives on the challenges and future directions.