The role of sonic hedgehog reemergence during gastric cancer.
The role of sonic hedgehog reemergence during gastric cancer.
复制标题
DOI：
10.1007/s10620-010-1252-z
复制
发表时间：
2010-06
影响因子：
3.1
通讯作者：
Zavros, Yana
中科院分区：
文献类型：
--
作者：
Martin, Jason;Donnelly, Jessica M.;Houghton, JeanMarie;Zavros, Yana
Sonic Hedgehog (Shh) signaling has been extensively studied for its role in developmental biology and cancer biology. The association between Shh and cancer development in general is well established but the functional role of Shh in the development and progression of gastric cancer specifically is largely unknown. Bone marrow-derived stem cells, specifically mesenchymal stem cells (MSCs) infiltrate and engraft into the gastric mucosa in response to the chronic inflammatory environment of Helicobacter infection. In this review, MSC infiltration and changes in the cytokine and cellular profiles of later-stage chronic environments will be tied into their interactions with the Shh pathway. We will discuss how these changes shape tumorigenesis and tumor progression in the gastric mucosa. The current review focuses on the Shh signaling pathway and its role in the development of gastric cancer, specifically in response to Helicobacter pylori infection. We follow with an in-depth discussion of the regulation of the Hedgehog pathway during acute and chronic gastric inflammation with a focus on signaling within the MSC compartment.
登录
查看更多内容
影响因子：
8.8
作者：
El-Zaatari, M;Tobias, A;Grabowska, A M;Kumari, R;Scotting, P J;Kaye, P;Atherton, J;Clarke, P A;Powe, D G;Watson, S A
通讯作者：
Watson, S A
DOI：
10.1152/ajpgi.00187.2006
发表时间：
2006-12-01
影响因子：
4.5
作者：
Goldenring, James R.;Nomura, Sachiyo
通讯作者：
Nomura, Sachiyo
影响因子：
3.1
作者：
Aihara, M;Tsuchimoto, D;Matsushima, K
通讯作者：
Matsushima, K
影响因子：
20.1
作者：
Haider, Husnain Kh;Jiang, Shujia;Ashraf, Muhammad
通讯作者：
Ashraf, Muhammad
影响因子：
3.1
作者：
Chu, SH;Kim, H;Kim, KH
通讯作者：
Kim, KH