Postnatal development of the dopamine transporter: A quantitative autoradiographic study
Postnatal development of the dopamine transporter: A quantitative autoradiographic study
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DOI：
10.1016/0165-3806(96)00004-1
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发表时间：
1996-04-30
期刊：
影响因子：
--
通讯作者：
Murrin, LC
中科院分区：
文献类型：
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作者：
Coulter, CL;Happe, HK;Murrin, LC
多巴胺转运蛋白在调节多巴胺能突触的神经化学传递以及多巴胺能神经元的多巴胺合成活性中起重要作用。某些药物和毒素对转运体产生影响，特别是可卡因，一种常见的滥用药物。我们使用可卡因类似物[I-125]RTI-55的定量放射自显影研究了出生后第0、5、10、15、21天和成年大鼠这些部位的发育。在出生时，某些结构，如黑质，内侧纵束，额叶和顶叶皮质，和inominata的间质核的[I-125]RTI-55结合水平已经接近成人的值。纹状体发育较晚，在前部和背外侧区域显示出较早的生长，早期定位于纹状体和胼胝体下条纹。在第0天存在前-后和侧-中梯度。前纹状体，腹侧被盖区，黑质和床核的终纹显示出短暂的峰值结合水平高于成人值。发育较晚的结构包括前额叶皮质、丘脑核壳、嗅结节和丘脑底核。不同脑区多巴胺转运蛋白的差异发育模式的知识可能对理解产前可卡因暴露对神经发育的影响有影响。
The dopamine transporter performs an important role in regulating neurochemical transmission at dopaminergic synapses, as well as dopamine synthetic activity in dopaminergic neurons. Certain drugs and toxins exert effects at the transporter, especially cocaine, a common drug of abuse. We studied the development of these sites in the rat at postnatal ages day 0, 5, 10, 15, 21 and adult using quantitative autoradiography with the cocaine analogue [I-125]RTI-55. At birth, certain structures such as the substantia nigra, interstitial nucleus of the medial longitudinal fasciculus, frontal and parietal cortex, and substantia inominata had [I-125]RTI-55 binding levels that were already near the adult value. The striatum developed later, showing earlier growth in the anterior and dorsolateral regions, with early localization in both striosomes and a subcallosal streak. Anterior-to-posterior and lateral-to-medial gradients were present at day 0. The anterior striatum, ventral tegmental region, substantia nigra compacta and bed nucleus of the stria terminalis showed transient peaks in binding levels that were higher than the adult values. Structures showing relatively late development included the prefrontal cortex, nucleus accumbens shell, olfactory tubercle and subthalamic nucleus. Knowledge of the differential development patterns of the dopamine transporter in different brain regions may have implications for understanding the neurodevelopmental effects of prenatal cocaine exposure.