The peroxiredoxin repair proteins.
The peroxiredoxin repair proteins.
复制标题
过氧化还原蛋白修复蛋白。
DOI：
10.1007/978-1-4020-6051-9_6
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发表时间：
2007
影响因子：
--
通讯作者：
Lowther,WTodd
中科院分区：
文献类型：
--
作者：
Jönsson,ThomasJ;Lowther,WTodd
Sulfiredoxin和sestrin是半胱氨酸亚磺酸还原酶，其选择性地还原或修复真核生物中典型的2-Cys过氧化物氧还蛋白的过氧化形式。因此，这些酶在过氧化物介导的细胞信号传导和细胞防御机制的调节中发挥关键作用。硫氧还蛋白的独特结构有助于接近过氧化物氧还蛋白活性位点和新型硫化学
Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry