Photophysical studies of tin(IV)-protoporphyrin: potential phototoxicity of a chemotherapeutic agent proposed for the prevention of neonatal jaundice.
Photophysical studies of tin(IV)-protoporphyrin: potential phototoxicity of a chemotherapeutic agent proposed for the prevention of neonatal jaundice.
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锡（IV）-原卟啉的光物理研究：用于预防新生儿黄疸的化疗剂的潜在光毒性。
DOI：
10.1073/pnas.85.14.5249
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发表时间：
1988
影响因子：
11.1
通讯作者：
Truscott,TG
中科院分区：
文献类型：
--
作者：
Land,EJ;McDonagh,AF;McGarvey,DJ;Truscott,TG
强吸光金属卟啉锡（IV）-原卟啉IX（SnPP）目前被认为是用于预防新生儿严重高胆红素血症的化学治疗剂，所述新生儿严重高胆红素血症是通常通过使用可见光的光疗来治疗的病症。为了评估SnPP的潜在光毒性，我们使用激光闪光光解和脉冲辐解研究了药物在水溶液和非水溶液中的光物理学。测量了形成三重态激发态SnPP的量子产率，沿着与三重态寿命和消光系数。此外，我们测量了量子产率的SnPP光敏形成的单线态氧在MeO 2 H和2 H2O含有十六烷基三甲基溴化铵，使用时间分辨发光技术。从单体基态SnPP形成三重态SnPP的量子产率高（约等于0.6-0.8），并且三重态寿命长（约等于0.1- 0.2ms）。观察到三重态SnPP被分子氧有效猝灭，速率常数大于10（9）M-1.s-1。SnPP-光敏形成的单线态氧在水和非水溶剂中被证实的特征发光在1270 nm（φ δ = 0.58在MeO 2 H）的检测。SnPP的光物理参数和单线态氧敏化效率与已知对人类具有光毒性的血卟啉和其他无金属卟啉所报道的那些相似。这些观察结果表明，由单线态氧损伤引起的皮肤光敏性可能是SnPP治疗的不良副作用。
The strongly light-absorbing metalloporphyrin tin(IV)-protoporphyrin IX (SnPP) is currently being considered as a chemotherapeutic agent for preventing severe hyperbilirubinemia in newborns, a condition usually treated by phototherapy with visible light. To assess the potential phototoxicity of SnPP we studied the photophysics of the drug in aqueous and nonaqueous solutions using laser flash photolysis and pulse radiolysis. Quantum yields for formation of triplet-state excited SnPP were measured, along with triplet lifetimes and extinction coefficients. In addition, we measured quantum yields for the SnPP-photosensitized formation of singlet oxygen in MeO2H and 2H2O containing cetyltrimethylammonium bromide, using a time-resolved luminescence technique. Quantum yields for formation of triplet SnPP from monomeric ground-state SnPP are high (approximately equal to 0.6-0.8), and triplet lifetimes are long (approximately equal to 0.1-0.2 ms). Efficient quenching of triplet SnPP by molecular oxygen was seen with rate constants greater than 10(9) M-1.s-1. SnPP-photosensitized formation of singlet oxygen in aqueous and nonaqueous solvents was confirmed by the detection of the characteristic luminescence at 1270 nm (phi delta = 0.58 in MeO2H). The photophysical parameters and singlet oxygen-sensitizing efficiency of SnPP are similar to those reported for hematoporphyrin and other metal-free porphyrins known to be phototoxic to humans. These observations suggest that cutaneous photosensitivity arising from singlet-oxygen damage is likely to be an undesirable side-effect of SnPP therapy.