Minimally invasive assessment of the effect of mannitol and hypertonic saline therapy on traumatic brain edema using measurements of reduced scattering coefficient (μs').
Minimally invasive assessment of the effect of mannitol and hypertonic saline therapy on traumatic brain edema using measurements of reduced scattering coefficient (μs').
复制标题
DOI：
10.1364/ao.49.005407
复制
发表时间：
2010-10
期刊：
影响因子：
1.9
通讯作者：
Jie-ru Xie;Z. Qian;Tian-ming Yang;Weitao Li;Guangxia Hu
中科院分区：
文献类型：
--
作者：
Jie-ru Xie;Z. Qian;Tian-ming Yang;Weitao Li;Guangxia Hu
应用微创功能近红外光谱技术（fNIR）评价甘露醇和高渗盐水（HS）治疗创伤性脑水肿（TBE）的疗效。建立TBE模型后，分别给予不同剂量的甘露醇或HS。利用微创fNIRs系统，在活体和真实的时间同步监测和记录大鼠局部皮层的约化散射系数μ（s ′）。分别于伤后1、6、24、72、120 h用湿重法和干重法测定脑含水量（BWC）。然后通过记录脱水前后的μ（s）'和BWC来评估用不同脱水剂治疗TBE的效果。本研究连续监测脑水肿的动态变化和脱水治疗的效果。结果提示，大鼠局部皮质μ（s）'是评价TBE治疗效果的良好指标。通过记录μ（s）′值的变化，得出以下结论：HS比甘露醇更有效地减轻脑水肿。HS的脱水效果仅与渗透梯度有关，与浓度无关。
Minimally invasive functional near infrared spectroscopy (fNIRs) technology was utilized to assess the effects of mannitol and hypertonic saline (HS) in treating traumatic brain edema (TBE). Rats with TBE models were given mannitol or HS in different dosages for different groups. The reduced scattering coefficient (μ(s)') of the local cortex of rats was simultaneously monitored and recorded in vivo and real time by the minimally invasive fNIRs system. Brain water content (BWC) was measured by the wet and dry weight method at 1, 6, 24, 72, and 120 h after injury and treatment. Effects of treating TBE with different dehydration agents were then assessed by recording μ(s)' and BWC before and after administration of dehydration. In this study, the dynamic changes of brain edema and the effects of dehydration therapy were continuously monitored. Results implied that μ(s)' of the local cortex in rats is a good indicator for assessing effects of treatment of TBE. By recording changes in the value of μ(s)', the following conclusions were obtained: HS is more effective than mannitol in reducing cerebral edema. The effect of dehydration of HS is only related to osmotic gradient and has no correlation with concentration.