Association Between Age-Related Hearing Loss and Stroke in an Older Population
Association Between Age-Related Hearing Loss and Stroke in an Older Population
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DOI：
10.1161/strokeaha.108.535682
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发表时间：
2009-04-01
期刊：
影响因子：
8.3
通讯作者：
Mitchell, Paul
中科院分区：
文献类型：
--
作者：
Gopinath, Bamini;Schneider, Julie;Mitchell, Paul
背景和目的：很少有研究调查听力损失和中风之间的关系。《中风》杂志最近的一篇文章报道，在5年的随访期间，突发性听力损失患者中风发病率增加。我们的研究旨在探讨代表性人群中与年龄相关的听力损失受试者之间的这种关联。此外，我们研究了老年人听力损失的严重程度与中风风险之间的关系，这被中风报告的作者认为是一个局限性。方法：蓝山听力研究是一项以人群为基础的年龄相关听力损失调查，于1997年至1999年和2002年至2004年在蓝山眼科研究的参与者中进行。听力学家测量0.25至8.0 kHz的纯音空气传导加热阈值。听力损失定义为较好耳中0.5、1.0、2.0和4.0 kHz频率的纯音平均值。结果：经多变量调整后，中度至重度听力损失患者报告既往卒中的可能性显著增加（OR, 2.04; 95% CI, 1.20-3.49）。然而，5年随访后，中度至重度听力损失并不能预测卒中的发生（OR, 1.14; 95% CI, 0.59-2.23）。结论：我们观察到卒中与中重度听力损失之间存在很强的横断面关联。然而，在我们的队列中，与年龄相关的听力损失并没有增加突发中风的风险。研究能力不足或突发性感音神经性听力损失和典型的年龄相关性听力损失的潜在病理不同可能是这些研究结果差异的原因。(中风。2009;40:1496 - 1498)。
Background and Purpose-Very few studies have investigated the association between hearing loss and stroke. A recent article in Stroke reported an increased incidence of stroke among patients with sudden hearing loss over a 5-year follow-up period. Our study aimed to explore this association among subjects with age-related hearing loss from a representative population. Further, we looked at the association between severity of hearing loss and risk of stroke in older persons, acknowledged as a limitation by the authors of the Stroke report.Methods-The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss conducted during 1997 to 1999 and 2002 to 2004, among participants of the Blue Mountains Eye Study. Pure-tone air conduction heating thresholds from 0.25 to 8.0 kHz were measured by audiologists. Hearing loss was defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 dB HL in the better ear.Results-Persons with moderate to severe hearing loss had a significantly higher likelihood of reporting previous stroke (OR, 2.04; 95% CI, 1.20-3.49) after multivariable adjustment. However, moderate to severe hearing loss did not predict incident stroke after 5-year follow-up (OR, 1.14; 95% CI, 0.59-2.23).Conclusions-We observed a strong cross-sectional association between stroke and moderate to severe hearing loss. However, age-related hearing loss did not increase risk of incident stroke in our cohort. Insufficient study power or differing underlying pathologies of sudden sensorineural hearing loss and typical age-related hearing loss may account for the discrepant findings between these studies. (Stroke. 2009;40:1496-1498.)