Factors influencing exercise performance in thoracic cancer
Factors influencing exercise performance in thoracic cancer
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DOI：
10.1016/j.rmed.2011.11.002
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发表时间：
2012-02-01
影响因子：
4.3
通讯作者：
Wilcock, Andrew
中科院分区：
文献类型：
--
作者：
England, Ruth;Maddocks, Matthew;Wilcock, Andrew
背景：无法治愈的胸部癌症患者经常抱怨运动能力下降，但对其原因的研究很少。因此，我们已经探讨了各种生理和心理因素与运动performance.Methods：吸气肌力，外周肌肉力量，肺功能和掌握呼吸困难进行了评估，分别使用鼻吸气压，腿伸肌力量，简单的肺功能和掌握领域的慢性呼吸系统疾病问卷。使用递增穿梭步行试验（ISWT）评估运动能力，在此期间，患者佩戴K4 B（2）系统，可测量静息和断点心率、每分钟通气量（VE）和摄氧量（VO 2）。使用相关系数和13个回归系数确定ISWT距离与四个因素之间的关系。41名患者（21名男性，平均（SD）年龄64（8）岁），行走中位数[IQR]为320 [250-430]米，平均（SD）为76（10），77（25），和48%（14%）分别预测最大心率、VO 2和VE。运动能力仅与吸气肌力（r = 0.42，P < 0.01）和外周肌力（r = 0.39，P = 0.01）显著相关。这些因素也是运动能力的重要决定因素（β系数[95%CI]分别为1.77 [0.53，3.01]和1.22 [0.31，2.14]）。结论：在所研究的因素中，只有吸气和外周肌肉的能力与运动能力显著相关并可预测运动能力。包括吸气和周围肌肉训练在内的康复干预措施值得在这组胸部癌症患者中进一步探索。(C)2011爱思唯尔有限公司保留所有权利。
Background: Patients with incurable thoracic cancer often complain of a reduced ability to exercise, but the cause of this has been little studied. Thus, we have explored how various physiological and psychological factors relate to exercise performance in this group.Methods: Inspiratory muscle strength, peripheral muscle power, lung function and mastery over breathlessness were assessed using sniff nasal inspiratory pressure, leg extensor power, simple spirometry and the mastery domain of the Chronic Respiratory Disease Questionnaire respectively. Exercise performance was assessed using the Incremental Shuttle Walking Test (ISWT) during which patients wore a K4 b(2) system permitting measurement of resting and breakpoint heart rate, minute ventilation (VE) and oxygen uptake (VO2). Relationships between ISWT distance and the four factors were determined using correlation and 13 regression coefficients.Results: Forty-one patients (21 male, mean (SD) age 64 (8) years) walked a median [IQR] of 320 [250-430] metres and reached a mean (SD) of 76 (10), 77 (25), and 48 (14) of their percent predicted maximum heart rate, VO2, and VE respectively. Exercise performance was significantly associated only with inspiratory muscle strength (r = 0.42, P < 0.01) and peripheral muscle power (r = 0.39, P = 0.01). These factors were also significant determinants of exercise performance (beta coefficients [95%CI] 1.77 [0.53, 3.01] and 1.22 [0.31, 2.14] respectively).Conclusion: Of the factors examined, only inspiratory and peripheral muscle performance were significantly related to and predictive of exercise performance. Rehabilitation interventions which include inspiratory and peripheral muscle training are worth exploring further in this group of patients with thoracic cancer. (C) 2011 Elsevier Ltd. All rights reserved.