The role of the circadian rhythms in critical illness with a focus on acute pancreatitis.
The role of the circadian rhythms in critical illness with a focus on acute pancreatitis.
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DOI：
10.1016/j.heliyon.2023.e15335
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发表时间：
2023-04
期刊：
影响因子：
4
通讯作者：
H. Waddell;T. J. Stevenson;D. Mole
中科院分区：
文献类型：
--
作者：
H. Waddell;T. J. Stevenson;D. Mole
昼夜节律负责调节各种生理过程，包括激素分泌、免疫反应、新陈代谢和睡眠/清醒周期。在急性胰腺炎(AP)等危重疾病中，由于疾病，昼夜节律可能会变得失调。证据表明，疾病的发病时间，加上AP带来的外周炎症，将影响中央起搏器和周围组织产生的昼夜节律。先天性和获得性免疫系统的细胞受昼夜节律控制，在疾病期间，昼夜表达模式可能会被打乱。免疫细胞昼夜节律释放和基因表达的高峰期可能与AP的发病相一致，这可能会增加胰腺损伤和组织损伤，并有可能发展为全身炎症和多器官衰竭。在这里，我们提供了AP中昼夜节律的作用和基础炎症机制的概述，以使正在进行的AP的时间生物学和时间疗法的研究背景。
Circadian rhythms are responsible for governing various physiological processes, including hormone secretion, immune responses, metabolism, and the sleep/wake cycle. In critical illnesses such as acute pancreatitis (AP), circadian rhythms can become dysregulated due to disease. Evidence suggests that time of onset of disease, coupled with peripheral inflammation brought about by AP will impact on the circadian rhythms generated in the central pacemaker and peripheral tissues. Cells of the innate and adaptive immune system are governed by circadian rhythms and the diurnal pattern of expression can be disrupted during disease. Peak circadian immune cell release and gene expression can coincide with AP onset, that may increase pancreatic injury, tissue damage and the potential for systemic inflammation and multiple organ failure to develop. Here, we provide an overview of the role of circadian rhythms in AP and the underpinning inflammatory mechanisms to contextualise ongoing research into the chronobiology and chronotherapeutics of AP.