A comprehensive review of genomic perspectives of canine diseases as a model to study human disorders.
A comprehensive review of genomic perspectives of canine diseases as a model to study human disorders.
复制标题
作为研究人类疾病模型的犬疾病基因组观点的全面综述。
DOI：
--
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
C. S. Mukhopadhyay
中科院分区：
文献类型：
--
作者：
Bhawanpreet Kaur;J. Kaur;N. Kashyap;J. Arora;C. S. Mukhopadhyay
家犬作为研究人类疾病遗传学的系统而受到相当大的关注。种群多样性和品种结构是使狗特别适合遗传学研究的独特特征。狗表现出品种特异性同质性的显着特征，这与显着的品种间异质性相关。这篇综述讨论了研究遗传图谱、全基因组关联研究 (GWAS) 的重要性以及该物种作为动物模型的有用性。大多数犬类遗传性疾病与人类相似，包括遗传性疾病、精神疾病和遗传性疾病。除了揭示新的候选基因外，犬类模型还允许获取实验资源，例如细胞、组织，甚至活体动物，以用于研究和干预目的。
The domestic dog has been given considerable attention as a system for investigating the genetics of human diseases. Population diversity and breed structure are unique features that make dogs particularly amenable to genetic studies. Dogs show distinguished features of breed-specific homogeneity, which is associated with striking interbreed heterogeneity. This review discusses the significance of studying the genetic maps, genome-wide association studies (GWAS), and usefulness of this species as an animal model. Most canine genetic disorders are similar to those of humans, including inherited, psychiatric, and genetic disorders. In addition to revealing new candidate genes, canine models allow access to experimental resources, such as cells, tissues, and even live animals, for research and intervention purposes.