Influence of breastfeeding in the accumulation of polybromodiphenyl ethers during the first years of child growth
Influence of breastfeeding in the accumulation of polybromodiphenyl ethers during the first years of child growth
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DOI：
10.1021/es070217u
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发表时间：
2007-07-15
影响因子：
11.4
通讯作者：
Grimalt, Joan O.
中科院分区：
文献类型：
--
作者：
Carrizo, Daniel;Grimalt, Joan O.
研究了在梅诺卡岛（西班牙巴利阿里岛）建立的队列中出生时（脐带血血清，n = 92）和4岁时（血清，n = 244）儿童的多溴联苯醚（PBDEs）浓度。这个队列是典型地中海饮食的一般欧洲人口的代表。在分析的13个同系物中，BDE #47在两种类型的样品中含量最高，脐带血血清脂质质量平均值为2.8 ng/g，血清脂质质量平均值为2.9 ng/g。所观察到的多溴二苯醚的分布与市售的五溴联苯醚混合物的组成相似。多数同系物的浓度在雌性中高于雄性，但差异不显著。母乳喂养的4岁儿童血清中多溴二苯醚含量高于配方奶喂养的儿童。浓度较高的同系物（如BDE #47和BDE #99）的差异具有统计学意义。这一差异与先前关于多氯联苯或4,4'-DDE的报告一致，表明尽管哺乳期较短（该队列中平均约为4.5个月），但母乳喂养是4岁时这些化合物的身体负担的决定因素。母乳喂养和配方奶喂养的儿童在出生至出生后头4年的平均总多溴二苯醚体负荷分别增加65和10 ng。
The concentrations of polybromodiphenyl ethers (PBDEs) in children at birth (cord blood sera, n = 92) and at the age of 4 years (sera, n = 244) from a cohort established in Menorca Island (Balearic Island, Spain) were studied. This cohort is representative of a general European population that is fed a typical Mediterranean diet. Among the 13 congeners analyzed, BDE #47 was the most abundant in both types of samples, with mean values of 2.8 ng/g of lipid weight in cord blood sera and 2.9 ng/g of lipid weight in sera. The observed distributions of PBDEs paralleled the composition of the commercially available mixtures of pentabromodiphenyl ethers. The concentrations of most congeners were higher in females than in males, but the differences were not significant. PBDE in the sera of 4 year old children was higher among those having been fed with maternal milk than formula. The differences were statistically significant for the congeners found in higher concentrations (e.g., BDE #47 and BDE #99). This difference was consistent with previous reports on polychlorobiphenyls or 4,4'-DDE, indicating that despite the short lactation period (about 4.5 months as an average in this cohort), breastfeeding was the determining factor for the body burden of these compounds at 4 years of age. The observed increases of average body burden of total PBDEs between birth and the first 4 years of growth were 65 and 10 ng for breastfed and formula fed children, respectively.