Zinc-releasing calcium phosphate cements for bone substitute materials
Zinc-releasing calcium phosphate cements for bone substitute materials
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DOI：
10.1016/j.ceramint.2016.08.027
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发表时间：
2016-11-15
影响因子：
5.2
通讯作者：
Rau, J. V.
中科院分区：
文献类型：
--
作者：
Graziani, V.;Fosca, M.;Rau, J. V.
本研究的目的是开发用于功能化骨移植应用的锌掺杂磷酸钙骨水泥（CPCs-Zn）。提出了一种水共沉淀法合成β -磷酸三钙（β - tcp）粉末样品，锌添加量从0 wt%到1.2 wt%，作为生产CPCs-Zn的替代方法，而不是机械混合粉末。利用能量色散x射线衍射技术实时监测CPCs-Zn （Zn = 0 wt%， 0.6 wt%和1.2 wt%）的结构转变和动力学。用扫描电镜观察了CPCs-Zn的微观结构发展。通过原子发射光谱测定，cpc - zn0.6 wt%和cpc - zn1.2 wt%水泥的锌离子释放量分别为0.30 +/- 0.01和0.10 +/- 0.01 μ g/L。抑菌试验结果表明，只有cpc - zn0.6 wt%水泥配方对致病性大肠杆菌有抑制作用。(C) 2016 Elsevier Ltd and Techna Group S.r.l版权所有
The goal of the present study was to develop zinc-doped calcium phosphate bone cements (CPCs-Zn) for functionalized bone grafts applications. An aqueous co-precipitation process for synthesis of beta-tricalcium phosphate (beta-TCP)powder samples with Zn addition ranging from 0 wt% up to 1.2 wt% was proposed as an alternative approach to produce CPCs-Zn, instead of mechanical mixing of powders. Real-time monitoring of structural transformations and kinetics of CPCs-Zn (Zn = 0 wt%, 0.6 wt% and 1.2 wt%) was carried out by the Energy Dispersive X-Ray Diffraction technique. The microstructure development in CPCs-Zn was investigated by Scanning Electron Microscopy. Zn-ion release from CPC-Zn 0.6 wt% and CPC-Zn 1.2 wt% cements, measured by the Atomic Emission Spectroscopy, corresponded to the average values of 0.30 +/- 0.01 and 0.10 +/- 0.01 mu g/L, respectively. The results of antibacterial tests proved the inhibitory effect towards pathogenic Escherichia coli only for the CPC-Zn 0.6 wt% cement formulation. (C) 2016 Elsevier Ltd and Techna Group S.r.l. All rights reserved.