Classical and operant conditioning differentially modify the intrinsic properties of an identified neuron
Classical and operant conditioning differentially modify the intrinsic properties of an identified neuron
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DOI：
10.1038/nn1593
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发表时间：
2006-01-01
影响因子：
25
通讯作者：
Byrne, JH
中科院分区：
文献类型：
--
作者：
Lorenzetti, FD;Mozzachiodi, R;Byrne, JH
神经科学中一个长期存在的争论是，经典条件反射和可操作性条件反射在机制上是相似的还是截然不同的。海兔的取食行为为解决这一问题提供了一个模型系统。在这里，我们报告了经典的和可操作的摄食行为的条件作用不同地改变了神经元B51的内在兴奋性，B51是表达摄食反应的关键元件，从而揭示了这两种形式的联想学习在细胞水平上的不同。
A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify the intrinsic excitability of neuron B51, a critical element for the expression of the feeding response, thus revealing that these two forms of associative learning differ at the cellular level.