Differential antioxidant and quinone reductase inducing activity of American, Asian, and Siberian ginseng
Differential antioxidant and quinone reductase inducing activity of American, Asian, and Siberian ginseng
复制标题
DOI：
10.1016/j.foodchem.2009.06.049
复制
发表时间：
2010-03-15
期刊：
影响因子：
8.8
通讯作者：
Blumberg, Jeffrey B.
中科院分区：
文献类型：
--
作者：
Chen, C. -Y. Oliver;Ribaya-Mercado, Judy D.;Blumberg, Jeffrey B.
美国，亚洲和西伯利亚人参的抗氧化剂和醌还原酶（QR）诱导活性已被报道使用各种植物材料，溶剂和测定。为了直接确定其比较生物活性，测试了从酸化甲醇（MeOH）、胃肠模拟物（GI）和己烷（Hex）中获得的提取物对自由基清除和QR诱导的影响。西伯利亚人参-甲醇具有最高的总酚含量为52.6 μ mol没食子酸当量/g。GI从美国和亚洲人参中释放的酚类物质比MeOH和Hex多>= 50%。西伯利亚人参-Hex在Hepa 1c 1c 7细胞中诱导QR活性最有效。美国人参和亚洲人参的GI和MeOH提取物表现出相当的HOCl清除活性，但比西伯利亚人参强>= 4.6倍。西伯利亚人参是ONOO-最有效的清除剂。西伯利亚-甲醇具有最高的铁还原抗氧化能力（FRAP），和美国人参-GI具有最高的氧自由基吸收能力（ORAC）。因此，人参中的成分具有抗氧化和QR诱导活性，这取决于剂量、提取方法、自由基种类和植物种类。(C)2009年由Elsevier Ltd.出版
The antioxidant and quinone reductase (QR) inducing activities of American, Asian, and Siberian ginseng have been reported using various plant materials, solvents, and assays. To directly establish their comparative bioactivity, the effects of extracts obtained from acidified methanol (MeOH), a gastrointestinal mimic (GI), and hexane (Hex) on free radical scavenging and QR induction were tested. Siberian ginseng-MeOH had the highest total phenolic content at 52.6 mu mol gallic acid equivalents/g. GI liberated >= 50% more phenolics than MeOH and Hex from American and Asian ginseng. Siberian ginseng-Hex was most effective at inducing QR activity in Hepa1c1c7 cells. GI and MeOH extracts of American and Asian ginseng exhibited comparable HOCl scavenging activity, but were >= 4.6-fold more potent than Siberian ginseng. Siberian ginseng was the most effective scavenger of ONOO-. Siberian-MeOH had the highest ferric reducing antioxidant power (FRAP), and American ginseng-GI had the highest oxygen radical absorbance capacity (ORAC). Thus, the components in ginseng have antioxidant and QR-inducing activity which are dependent upon the dose, method of extraction, radical species, and plant species. (C) 2009 Published by Elsevier Ltd.