Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy?
Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy?
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DOI：
10.1111/j.1527-5299.2005.04457.x
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发表时间：
2005-09-01
期刊：
影响因子：
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通讯作者：
Plehn, Jonathan F
中科院分区：
文献类型：
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作者：
Shizukuda, Yukitaka;Sachdev, Vandana;Plehn, Jonathan F
非梗阻性肥厚型心肌病（NHCM）患者运动能力降低的潜在机制可能包括心室舒张、舒张顺应性或代偿性心房收缩功能的紊乱。我们假设NHCM患者心房收缩力的丧失导致功能能力降低。为了验证这一假设，我们比较了49例连续NHCM患者（年龄36 ± 10岁; 41%为女性）和正常左心室射血分数（平均68% ± 8%）的静息无创左心房射血相指数与客观代谢运动参数。左心房主动排空分数、射血力和动能不能预测运动能力。只有左心房总排空量和主动排空量与分钟通气量/二氧化碳产生斜率弱相关（r=0.31和r=0.33; p
The mechanisms underlying reduced exercise capacity in patients with nonobstructive hypertrophic cardiomyopathy (NHCM) could include perturbations of ventricular relaxation, diastolic compliance, or compensatory atrial systolic function. We hypothesized that a loss of atrial contractility in NHCM patients leads to reduced functional capacity. To test this hypothesis, we compared resting noninvasive left atrial ejection phase indices in 49 consecutive patients with NHCM (ages 36+/-10 years; 41% female) and normal left ventricular ejection fraction (mean, 68%+/-8%) with objective metabolic exercise parameters. Left atrial active emptying fraction, ejection force, and kinetic energy failed to predict exercise capacity. Only left atrial total and active emptying volumes correlated weakly with minute volume/CO2 production slope (r=0.31 and r=0.33; p