Interleukin-1
Interleukin-1
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DOI：
10.1016/s1357-2725(98)00081-8
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发表时间：
1998-10-01
影响因子：
4
通讯作者：
Saklatvala, J
中科院分区：
文献类型：
--
作者：
Stylianou, E;Saklatvala, J
白细胞介素1（IL 1）是炎症和免疫反应的主要调节因子。通过其I型受体，它激活特异性蛋白激酶，包括NF κ B诱导激酶（NIK）和三种不同的促分裂原活化蛋白（MAP）激酶级联。这些调节许多转录因子，包括NF κ B、AP 1和CREB，其中每一种都调节大量对炎症反应至关重要的立即早期基因。可溶性I型受体和IRAP的I期临床试验表明，它们具有潜在的抗炎作用。(C)1998爱思唯尔科技有限公司版权所有。
Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades. These modulate a number of transcription factors including NF kappa B, AP1 and CREB each of which regulate a plethora of immediate early genes central to the inflammatory response. Phase I clinical trials of the soluble type I receptor and IRAP indicate that these have potential anti-inflammatory effects. (C) 1998 Elsevier Science Ltd. All rights reserved.