Neutrophil kinetics shortly after initial administration of recombinant human granulocyte colony‐stimulating factor: Neutrophil alkaline phosphatase activitv as an endorrenous marker
Neutrophil kinetics shortly after initial administration of recombinant human granulocyte colony‐stimulating factor: Neutrophil alkaline phosphatase activitv as an endorrenous marker
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初次施用重组人粒细胞集落刺激因子后不久的中性粒细胞动力学：中性粒细胞碱性磷酸酶活性作为内分泌标记物
DOI：
10.1111/j.1600-0609.1992.tb00908.x
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发表时间：
1992
影响因子：
3.1
通讯作者：
S. Kitagawa
中科院分区：
文献类型：
--
作者：
M. Katoh;T. Shirai;Ken Shikoshi;M. Ishii;M. Saito;S. Kitagawa
Abstract: Recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) was administered (1.5 pg/kg body weight) subcutaneously once daily for 5 to 9 days to 5 patients with malignant lymphoma. In all patients, initial administration of rhG‐CSF induced a rapid fall in the neutrophil count within 30 minutes, followed by a recovery and an increase in the neutrophil count within 150 min. A rapid fall in the neutrophil count was accompanied by increased expression of neutrophil C3bi‐receptors, and neutrophils left in the circulation had lower activity of neutrophil alkaline phosphatase (NAP) and phagocytosis. A decrease in the NAP scores observed at 30 min reflected a preferential decrease of neutrophils with high NAP activity. A recovery and an increase in the neutrophil count were accompanied by a further decrease of NAP scores, which was caused by a preferential increase of neutrophils with lower NAP activity. The NAP scores of mature neutrophils from peripheral blood were not affected by in vitro treatment of cells with rhG‐CSF for up to 150 min at 37 °C. These findings and the previous observations that neutrophils in the circulating and marginal pools have high NAP activity and neutrophils in the bone marrow pool have low NAP activity taken together suggest that, following initial administration of rhG‐CSF, functionally active neutrophils leave the bloodstream preferentially, which is primarily followed by an influx of neutrophils from the bone marrow, but not by demargination of sequestered neutrophils.
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iC3b 受体 (CR3) 的上调对于促进中性粒细胞聚集既不是必要的也不是充分的。
DOI：
10.1172/jci113623
发表时间：
1988
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Philips,MR;Buyon,JP;Winchester,R;Weissmann,G;Abramson,SB
通讯作者：
Abramson,SB
影响因子：
4.4
作者：
R. Sullivan;J. Griffin;E. Simons;A. Schafer;T. Meshulam;J. Fredette;A. K. Maas;A. Gadenne;J. L. Leavitt;D. Melnick
通讯作者：
R. Sullivan;J. Griffin;E. Simons;A. Schafer;T. Meshulam;J. Fredette;A. K. Maas;A. Gadenne;J. L. Leavitt;D. Melnick
血液透析粒细胞减少症中促粘附表面糖蛋白的表达增加。
DOI：
10.1056/nejm198502213120801
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Arnaout,MA;Hakim,RM;Todd3rd,RF;Dana,N;Colten,HR
通讯作者：
Colten,HR
影响因子：
56.9
作者：
SOUZA, LM;BOONE, TC;WELTE, K
通讯作者：
WELTE, K
影响因子：
158.5
作者：
GABRILOVE, JL;JAKUBOWSKI, A;SOUZA, L
通讯作者：
SOUZA, L