Calretinin co-localizes with the NMDA receptor subunit NR1 in cholinergic amacrine cells of the rat retina
Calretinin co-localizes with the NMDA receptor subunit NR1 in cholinergic amacrine cells of the rat retina
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DOI：
10.1016/s0006-8993(00)02364-7
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发表时间：
2000-06-30
期刊：
影响因子：
2.9
通讯作者：
Hamassaki-Britto, DE
中科院分区：
文献类型：
--
作者：
Araki, CM;Hamassaki-Britto, DE
免疫组织化学方法检测大鼠视网膜胆碱-乙酰胆碱转移酶是否与钙结合蛋白和NMDA受体亚单位NR1共定位。在胆碱能无长突细胞中未见钙结合蛋白和小白蛋白的表达，但钙结合蛋白和NR1与胆碱能无长突细胞中胆碱能无长突细胞共存的频率较高。Calretinin/NR1阳性细胞也可见，提示大鼠胆碱能细胞中的Calretinin可能与缓冲NMDA受体激活所产生的过量细胞内钙有关。(C)2000 Elsevier Science B.V.保留所有权利。
Immunohistochemistry was used to verify whether choline-acetiltransferase colocalizes with calcium-binding proteins and NMDA receptor subunit NR1 in the rat retina. Whereas calbindin and parvalbumin were not observed in cholinergic amacrine cells, calretinin and NR1 were very frequently colocalized with ChAT. Calretinin/NR1-positive cells were also shown, suggesting that calretinin in cholinergic cells of the rat may be related to the buffering of excess intracellular calcium generated by activation of NMDA receptors. (C) 2000 Elsevier Science B.V. All rights reserved.