Increased aberrance of cytokine expression in plasma of patients with more advanced squamous cell carcinoma of the head and neck
Increased aberrance of cytokine expression in plasma of patients with more advanced squamous cell carcinoma of the head and neck
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DOI：
10.1016/j.cyto.2003.11.005
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发表时间：
2004-03-07
期刊：
影响因子：
3.8
通讯作者：
Young, MRI
中科院分区：
文献类型：
--
作者：
Lathers, DMR;Young, MRI
头颈部鳞状细胞癌（HNSCC）患者倾向于Th2表型，因为他们Th2细胞因子11-4、IL-6和IL-10水平升高，Th1细胞因子ifn - γ水平降低。然而，这种偏倚是不完全的，因为Th1细胞因子IL-2和GM-CSF的水平升高。本研究检测了101例HNSCC患者和40例年龄匹配且无已知恶性肿瘤的对照者血浆中Th1和Th2细胞因子水平之间的相互关系。对照组显示IL-1、IL-2、IL-4和ifn - γ水平之间以及GM-CSF和tgf - β之间存在广泛的相互关系。HNSCC患者IL-2、IL-4、ifn - γ和GM-CSF水平存在相关性，但相关性不显著。突出的是细胞因子水平与疾病负担增加之间的相关性下降，因此在T4期患者中没有任何细胞因子之间的关系。尽管淋巴结疾病的影响不如肿瘤负担那么突出，但淋巴结受累也与细胞因子水平相互之间更加独立有关。这些结果显示HNSCC患者部分Th2细胞因子偏倚，并且随着疾病的进展，细胞因子的表达逐渐变得更加异常。(C) 2004 Elsevier Ltd.版权所有。
Patients with head and neck squamous cell carcinoma (HNSCC) are biased toward the Th2 phenotype as they have increased levels of the Th2 cytokines 11-4, IL-6 and IL-10 and diminished levels of the Th1 cytokine IFN-gamma. However, this bias is incomplete since levels of the Th1 cytokines IL-2 and GM-CSF are increased. This study examined the interrelationship among the plasma levels of Th1 and Th2 cytokines in 101 HNSCC patients and 40 age-matched controls without a known malignancy. Control subjects showed extensive interrelationships among levels of IL-1, IL-2, IL-4, and IFN-gamma, as well as between GM-CSF and TGF-beta. HNSCC patients showed an interrelationship in levels of IL-2, IL-4, IFN-gamma and GM-CSF, but to a less significant degree. What was prominent was a decline in correlation among cytokine levels with increased disease burden, such that there were no relationships among any of the cytokines in stage T4 patients. Nodal involvement also was associated with cytokine levels being more independent of each other, although the impact of nodal disease was less prominent than tumor burden. These results show a partial Th2 cytokine bias in HNSCC patients and a progressively more aberrant expression of cytokines with more advanced disease. (C) 2004 Elsevier Ltd. All rights reserved.