Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes
Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes
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DOI：
10.1016/j.diabres.2010.03.018
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发表时间：
2010-07-01
影响因子：
5.1
通讯作者：
Mathiesen, E.
中科院分区：
文献类型：
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作者：
Christiansen, M. S.;Hesse, D.;Mathiesen, E.
目的：我们评估了尿类粘液排泄物 (UOE) 作为 1 型糖尿病孕妇先兆子痫和早产的生物标志物。方法：纳入患有孕前 1 型糖尿病的单胎孕妇，前提是在 17 孕周前收集了一份尿液样本。通过免疫比浊法分析血清和尿液中的类粘蛋白。主要结果测量是先兆子痫的发生（血压 > 140/90 mmHg 和蛋白尿）和 37 周前早产。结果：总共纳入了 173 名女性。怀孕期间UOE 增加。 20 名女性患有先兆子痫，其中 65 名女性早产。通过逻辑回归分析，我们发现 UOE > 1.37 mg/l（OR：6.85（95% CI：1.97-23.88；p 120 mmHg (4.12 (1.35-12.59)；p < 0.02））和糖尿病病程 > 20 年（3.69 (1.18-11.52)；p < 0.03）独立预测病情发展早产的独立预测因素是糖尿病病程和 HbA1c > 7%。回归模型中包含的其余协变量是 BMI、血清肌酐、吸烟和微量白蛋白尿。结论：妊娠早期 UOE 增加可预测妊娠前 1 型糖尿病女性的先兆子痫，与早产无关 (C) 2010 Elsevier Ireland。有限公司保留所有权利。
Aims: We evaluated the urinary orosomucoid excretion (UOE) as a biomarker of preeclampsia and preterm delivery in pregnant women with type 1 diabetes.Methods: Singleton pregnant women with pregestational type 1 diabetes were included provided one urine sample had been collected before 17 gestational weeks. Serum and urinary orosomucoid were analysed by immunoturbidimetry. Primary outcome measurements were development of preeclampsia (blood pressure > 140/90 mmHg and proteinuria) and preterm delivery before 37 weeks.Results: In total 173 women were included. The UOE increased during pregnancy. Preeclampsia developed in 20 women and 65 women delivered preterm. Using logistic regression analysis we found that UOE > 1.37 mg/l (OR: 6.85 (95% CI: 1.97-23.88; p 120 mmHg (4.12 (1.35-12.59); p < 0.02) and duration of diabetes > 20 years (3.69 (1.18-11.52); p < 0.03) independently predicted the development of preeclampsia. Independent predictors of preterm delivery were duration of diabetes and HbA1c > 7%. The remaining covariates included in the regression models were BMI, serum creatinine, smoking and microalbuminuria.Conclusions: Increased UOE early in pregnancy predicted preeclampsia in women with pregestational type 1 diabetes independently of albuminuria and other known risk factors. No association to preterm delivery was found. (C) 2010 Elsevier Ireland Ltd. All rights reserved.