RETINAL WOUND-HEALING - CELLULAR-ACTIVITY AT THE VITREORETINAL INTERFACE
RETINAL WOUND-HEALING - CELLULAR-ACTIVITY AT THE VITREORETINAL INTERFACE
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DOI：
10.1001/archopht.1986.01050140139037
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发表时间：
1986-02-01
影响因子：
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通讯作者：
RYAN, SJ
中科院分区：
文献类型：
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作者：
MILLER, B;MILLER, H;RYAN, SJ
用光学显微镜和电子显微镜研究了兔眼全层视网膜创伤后玻璃体视网膜界面的细胞活性。神经胶质细胞最初在伤口周围的视网膜表面生长。这一短暂的神经胶质增生与创伤后炎症反应有关，更具体地说，与吞噬单核细胞在玻璃体视网膜界面的积聚有关。一旦炎症消退，这种在视网膜表面生长膜的失败尝试停止，真正的视网膜前膜没有发展。我们的观察结果表明，眼内炎症和巨噬细胞反应决定了损伤的视网膜表面愈合和瘢痕形成的程度，因此可能在视网膜前膜的发病机制中发挥关键作用。
Cellular activity at the vitreoretinal interface after full-thickness retinal wounds was studied in rabbit eyes, using light and electron microscopy. Glial cell extensions grew initially on the retinal surface around the wound site. This brief period of glial proliferation was associated with the posttraumatic inflammatory responses and, more specifically, with phagocytic monocyte accumulation at the vitreoretinal interface. Once the inflammation subsided, this abortive attempt to grow membranes on the retinal surface stopped and true epiretinal membranes did not develop. Our observations suggest that intraocular inflammation and macrophage response determine the extent of healing and scarring on an injured retinal surface, and thus may play a key role in the pathogenesis of epiretinal membranes.