A simple Cu-64 production and its application of Cu-64 ATSM
A simple Cu-64 production and its application of Cu-64 ATSM
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DOI：
10.1016/j.apradiso.2009.02.060
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发表时间：
2009-07-01
影响因子：
1.6
通讯作者：
Cheon, Gi Jeong
中科院分区：
文献类型：
--
作者：
Kim, Jung Young;Park, Hyun;Cheon, Gi Jeong
其中一种正电子发射放射性核素Cu-64已被报道为PET成像研究中一种特别有效的放射性同位素。Cu-64的这种效用取决于其在水中的化学稳定性，并具有适当的能量和半衰期。因此，我们试图开发一种简单的方法来生产这种同位素，使用我们站点的旧回旋加速器模型（50 MeV, Scantronics co.）。特别设计了富集Ni-64电镀系统和放射性Cu-64塑料筒柱分离装置；在金箔上镀Ni-64系统，该系统以13度角对准光束照射。针对Cu-64的核反应，将其应用于Ni-64(p, n) Cu-64在Al和Ta箔组成的降解器下进行低能反应。束流照射后，用安装在HPGe探测器上的多通道分析仪对Cu-64进行鉴定，并通过Cu-64- atsm（前文报道的CT-26荷瘤小鼠）的微pet图像验证其有效性。Cu-64的成像质量也与F-18放射性同位素在微pet扫描仪上的成像质量非常相似。总之，在高能旧回旋加速器上成功地建立了一种生产Cu-64的方法及其应用。2009爱思唯尔有限公司版权所有。
One of the positron emission radionuclides, Cu-64, has been reported to be a particularly effective radioisotope in PET imaging study. This utility of Cu-64 depends on the chemical stability in water with proper energy and half-life as gamma-emitters.Hence, we tried to develop a simple method for producing this isotope using an old cyclotron model in our site (50 MeV, Scantronics co.). In particular, we designed the equipments of enrich Ni-64 plating system and radioactive Cu-64 separation using plastic cartridge column; Ni-64 plating system on gold foil which located in the 13 degrees angle target toward beam irradiation. For the nuclear reaction of Cu-64, it Was applied to Ni-64(p, n) Cu-64 at low energy under the degrader composed of Al and Ta foils. After beam irradiation, Cu-64 was identified by multichannel analyzer installed for a HPGe detector and its utility was certified by the microPET images of Cu-64-ATSM (CT-26 tumor bearing mouse as reported previously). The image quality of Cu-64 was also very similar to that of F-18 radioisotope in microPET scanner. In conclusion, a method of Cu-64 production and its application was successfully established in old cyclotron having high energy. (C) 2009 Elsevier Ltd. All rights reserved.