Numerical investigation on red blood cell dynamics in microflow: Effect of cell deformability
Numerical investigation on red blood cell dynamics in microflow: Effect of cell deformability
复制标题
DOI：
10.3233/ch-16128
复制
发表时间：
2017-01-01
影响因子：
2.1
通讯作者：
Kim, Sangho
中科院分区：
文献类型：
--
作者：
Ju, Meongkeun;Leo, Hwa Liang;Kim, Sangho
血管壁附近红细胞 (RBC) 的径向分散可以显着影响小血管中的运输动力学。红细胞的径向分散主要是由红细胞之间的碰撞引起的，并且可以通过聚集来增强这种碰撞。本研究的目的是数值研究红细胞变形能力对一定流速范围内单个红细胞径向运动的影响。浸没边界 - 格子玻尔兹曼方法用于研究红细胞在二维流域中的径向运动。红细胞流动模拟是在直径为25μm、长度为100μm的微血管中以40％血细胞比容进行的。在所有流速下，变形较小的红细胞的分散度均明显大于正常红细胞的分散度，并且当流速增加时，这种效应似乎更加明显。无论流速和红细胞变形能力如何，血管壁附近的细胞分散度都高于流动中心。因此，红细胞的分散可以通过流速和红细胞刚性来增强。我们的发现对于研究小动脉和小静脉的血流特别有用。
The radial dispersion of red blood cells (RBCs) near the vessel wall can significantly affect the transport dynamics in small vessels. The radial dispersion of RBCs is mainly caused by collisions between RBCs and this can be enhanced by aggregation. The objective of this study is to numerically investigate on the effect of RBC deformability on the radial motion of individual RBCs in a range of flow rates. Immersed Boundary - Lattice Boltzmann Method was utilized to study the radial motion of RBCs in a two-dimensional flow domain. The RBC flow simulations were performed at 40% hematocrit in a microvessel with diameter of 25 mu m and length of 100 mu m. The dispersion of less deformable RBCs was notably greater than that of normal RBCs at all flow rates and this effect seemed to be more pronounced when the flow rate was increased. The cell dispersion was higher near the vessel wall than the flow center regardless of flow rate and RBCs deformability. Thus, the dispersion of RBCs could be enhanced with flow rate and RBC rigidity. Our findings would be especially useful in investigating blood flows in arterioles and venules.