Existence and consequences of G-quadruplex structures in DNA
Existence and consequences of G-quadruplex structures in DNA
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DOI：
10.1016/j.gde.2013.10.012
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发表时间：
2014-04-01
影响因子：
4
通讯作者：
Balasubramanian, Shankar
中科院分区：
文献类型：
--
作者：
Murat, Pierre;Balasubramanian, Shankar
虽然60年前b型DNA的发现定义了我们对遗传密码的分子观点，但其他假设的DNA二级结构，如a -DNA、Z-DNA、H-DNA、十字形和滑动结构，已经引起了人们对DNA作为一种更动态结构的考虑。四链g -四重体DNA不使用沃森-克里克碱基配对，在过去十年中一直是相当多的猜测和研究的主题，特别是关于其与基因组完整性和基因表达的潜在相关性。在这里，我们讨论了最近的数据，这些数据共同支持基因组DNA中g -四联体的形成以及这种结构基序在生物过程中形成的后果。
While the discovery of B-form DNA 60 years ago has defined our molecular view of the genetic code, other postulated DNA secondary structures, such as A-DNA, Z-DNA, H-DNA, cruciform and slipped structures have provoked consideration of DNA as a more dynamic structure. Four-stranded G-quadruplex DNA does not use Watson-Crick base pairing and has been subject of considerable speculation and investigation during the past decade, particularly with regard to its potential relevance to genome integrity and gene expression. Here, we discuss recent data that collectively support the formation of G-quadruplexes in genomic DNA and the consequences of formation of this structural motif in biological processes.