Shorter survival of SDF1-3′Al3′A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type I infection
Shorter survival of SDF1-3′Al3′A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type I infection
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DOI：
10.1086/315650
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发表时间：
2000-07-01
影响因子：
6.4
通讯作者：
Vicenzi, E
中科院分区：
文献类型：
--
作者：
Brambilla, A;Villa, C;Vicenzi, E
SDF-1 3 'A等位基因多态性对人类免疫缺陷病毒1型（HIV-1）疾病的进展有积极或消极的影响。因此，确定了来自3个不同队列的729名HIV-1感染者的SDF-1基因型。在血清转换者（n = 319）中，SDF 1 - 3 'A1 - 3'A基因型与加速疾病进展之间的统计学无显著相关性，但与根据1993年定义诊断为AIDS或CD 4（+）T细胞计数丢失后生存率降低显著相关
The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3'Al3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4(+) T cell counts