Serotonectin and the family of proteins that bind serotonin.
Serotonectin and the family of proteins that bind serotonin.
复制标题
血清素和结合血清素的蛋白质家族。
DOI：
10.1016/0006-2952(84)90065-0
复制
发表时间：
1984
影响因子：
5.8
通讯作者：
Tamir,H
中科院分区：
文献类型：
--
作者：
Gershon,MD;Tamir,H
5-羟色胺(5-羟色胺；5-羟色胺)是一种非常活跃的生物胺。自1948年发现以来，关于它的论文发表的数量[L]证明，从很多方面来看，它都是药理学家的喜悦。很少组织不受5-羟色胺的影响。对5-羟色胺有反应的系统包括内分泌系统、神经系统和心血管系统。S-羟色胺对这样的系统有太多的作用，可以如此深刻地影响如此多不同的身体功能，使得5-羟色胺不仅是一种有趣的物质，而且也是一种潜在的危险物质。进化似乎保留了5-羟色胺，在几个器官系统的生理学中发挥着不同的作用，但在这样做的过程中，它显然保护了生物体免受大量释放自由、活跃、循环的5-羟色胺的幽灵的影响。这种可能性的危险在小鼠身上的致命性过敏反应现象中得到了很好的说明，这种反应的特征是血管崩溃，并由5-羟色胺介导[5]。对循环中的5-羟色胺的防御可以比作美国和苏联的核政策。威慑的主导原则似乎是冗余，而不是充足。进入循环的5-羟色胺主要通过肺摄取和清除失活，这一过程中肺内皮细胞起关键作用[6，7]。肝脏的代谢[8，9]和血小板的摄取[10]支持肺的清除。此外，最近在血液中发现了一种循环蛋白，它具有与5-羟色胺[11,121]结合的显著特性，并能与血液中的细胞元素结合[13,141]。这种蛋白质，5-羟色胺，是一种不同的5-羟色胺结合蛋白家族中的一种，这些蛋白是生殖层特异的。最近发现的2型(S2)5-羟色胺受体拮抗剂酮丝氨酸作为降压药的有效性[15，16]，表明针对游离5-羟色胺循环的精细防御阵列的缺陷可能与某些类型的高血压疾病的发病有关。这种可能性反过来又使5-羟色胺结合蛋白家族具有潜在的临床和生理意义。第一个被广泛鉴定的5-羟色胺结合蛋白是在大脑匀浆中发现的，称为5-羟色胺结合蛋白。这种蛋白质在大脑和脊髓区域的活性与5-羟色胺的浓度平行[20]。
Serotonin (5hydroxytryptamine; 5-HT) is an extraordinarily active biogenic amine. In many ways it has proved to be a pharmacologist’s delight, as the number of papers about it published since its discovery in 1948 [l] attest. Few tissues are unaffected by 5-HT. Among the systems that respond to 5-HT are the endocrine [2], nervous [3], and cardiovascular [4]. The plethora of actions that S-HT has on systems such as these, that can so profoundly influence so many diverse bodily functions, makes 5-HT not only an interesting substance but a potentially dangerous one as well. Evolution appears to have preserved 5-HT to carry out a variety of roles in the physiology of several organ systems, but in doing so it has clearly protected organisms against the spectre of the significant release of free, active, circulating 5-HT. The danger of that eventuality is well illustrated by the phenomenon of lethal anaphylaxis in mice, a reaction characterized by vascular collapse and mediated by 5-HT [5].Defenses against circulating 5-HT can be likened to American and Soviet nuclear policy. The governing principle of deterrence seems to be redundancy rather than sufficiency. 5-HT reaching the circulation is primarily inactivated by uptake and removal by the lung, a process in which the pulmonary endothelial cells play the critical role [6, 7]. Removal by the lung is backed up by hepatic metabolism [8, 9] and uptake into platelets [lo]. In addition, a circulating protein has been found recently in the blood that has the remarkable property of being able both to bind 5-HT [ll, 121 and to bind to cellular elements of the blood [13, 141. This protein, serotonectin, is one of a family of different serotonin-binding proteins that are germ-layer specific. The recently discovered effectiveness of the type 2 (S2) 5-HT receptor antagonist ketanserin, as an anti-hypertensive agent [15, 16], suggests that a defect in the elaborate array of defenses against the circulation of free 5-HT may be involved in the pathogenesis of some types of hypertensive disease. This possibility, in turn, makes the family of 5-HT binding proteins of potential clinical as well as physiological interest. The first 5-HT binding protein to be extensively characterized was found in homogenates of brain and called serotonin binding protein@ BP;[17-191). The activity of this protein in brain and spinal cord regions parallels the concentration of 5-HT [20].