Chemoradiation for primary invasive squamous carcinoma of the vagina
Chemoradiation for primary invasive squamous carcinoma of the vagina
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DOI：
10.1111/j.1048-891x.2004.014066.x
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发表时间：
2004-01-01
影响因子：
4.8
通讯作者：
Smith, LH
中科院分区：
文献类型：
--
作者：
Dalrymple, JL;Russell, AH;Smith, LH
目的：报告的结果与原发性，浸润性，鳞状细胞癌的阴道治疗与chemoradiation.Methods：在1986年和1996年之间，14例患者进行了初步治疗，包括同步放疗和化疗。根据肿瘤大小、位置以及与泌尿、肠道或性功能相关的问题，判断患者不适合手术。3例患者为FIGO I期，10例患者为II期，1例患者为III期。放射治疗包括单独的远距离治疗（6例患者）或与阴道内近距离治疗（8例患者）相结合。总辐射剂量范围为5700至7080 cGy（中位数6300 cGy）。化疗包括5-氟尿嘧啶单独（7例），或与顺铂（6例）或丝裂霉素C（1例）。结果：1例患者局部失败，在7个月，11个月死于疾病。4名患者死于并发疾病（46、92、104、109个月），9名患者在治疗后74-168个月（中位数100个月）存活且无癌症。结论：放疗同步化疗是治疗阴道鳞癌的有效方法。癌症控制结果与以前发表的采用更高剂量放射作为单一疗法的结果相比是有利的。
Objective: To report outcomes for patients with primary, invasive, squamous carcinoma of the vagina treated with chemoradiation.Methods: Between 1986 and 1996, 14 patients were treated with primary therapy consisting of synchronous radiation and chemotherapy. Patients were judged not to be surgical candidates based on tumor size, location, and concerns related to urinary, bowel, or sexual function. Three patients were FIGO stage I, ten patients stage II, and one patient stage III. Radiation consisted of teletherapy alone (six patients) or in combination with intravaginal brachytherapy (eight patients). Total radiation dose ranged from 5700 to 7080 cGy (median 6300 cGy). Chemotherapy consisted of 5-fluorouracil alone (seven patients), or with cisplatin (six patients) or mitomycin-C (one patient).Results: One patient failed locally at 7 months and died of disease at 11 months. Four patients died of intercurrent illness (46, 92, 104, 109 months) and nine are alive and cancer-free 74-168 months after treatment (median 100 months). There were no vesicovaginal or enterovaginal fistulae.Conclusions: Radiation with synchronous chemotherapy is an effective treatment for squamous carcinoma of the vagina. Cancer control outcomes compare favorably with previously published results employing higher dose radiation as monotherapy.