Rh-catalyzed cyclization of diynes and enynes initiated by carbonyl-directed activation of aromatic and vinylic C-H bonds.
Rh-catalyzed cyclization of diynes and enynes initiated by carbonyl-directed activation of aromatic and vinylic C-H bonds.
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DOI：
10.1021/ol0711669
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发表时间：
2007-07
期刊：
影响因子：
5.2
通讯作者：
K. Tsuchikama;Y. Kuwata;Yu-ki Tahara;Y. Yoshinami;T. Shibata
中科院分区：
文献类型：
--
作者：
K. Tsuchikama;Y. Kuwata;Yu-ki Tahara;Y. Yoshinami;T. Shibata
Rh催化的二炔与芳基酮或烯酮的氢芳基化和氢乙烯基化环化反应生成单环1，3-二烯。Enynes也进行了同样的反应，在手性Rh催化剂上得到了高ee的手性产物。芳香族和乙烯基C-H键的羰基活化很可能是目前转化的第一步。
The Rh-catalyzed hydroarylative and hydrovinylative cyclization of diynes with aryl ketones or enones gave monocyclic 1,3-dienes. Enynes also underwent the same reaction and chiral products were obtained with high ee using a chiral Rh catalyst. Carbonyl-directed activation of aromatic and vinylic C-H bonds is likely the initial step in the present transformation.