Kinetic Resolution of α-Nitrolactones by Catalytic Asymmetric Hydrolysis or Ester-Amide Exchange Reaction
Kinetic Resolution of α-Nitrolactones by Catalytic Asymmetric Hydrolysis or Ester-Amide Exchange Reaction
复制标题
通过催化不对称水解或酯酰胺交换反应动力学拆分 α-硝基内酯
DOI：
10.1055/s-0040-1707303
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发表时间：
2020
期刊：
影响因子：
2
通讯作者：
Mizoguchi Haruki
中科院分区：
文献类型：
--
作者：
Sakakura Akira;Nakao Ryota;Fujii Yudai;Hayakawa Ichiro;Mizoguchi Haruki
C1-对称手性铵盐催化剂通过不对称酯-酰胺交换反应诱导外消旋α-硝基内酯的动力学拆分。得到了具有高对映选择性和高S（=kfast/kslow）值的相应酰胺。该反应体系是合成手性α-硝基酰胺类碳环季铵盐的有效途径。
C1-Symmetric chiral ammonium salt catalysts induced a kinetic resolution of racemic α-nitrolactones through an asymmetric ester–amide exchange reaction. The corresponding amides were obtained with high enantioselectivities and highS(=kfast/kslow) values. This reaction system is a useful approach for obtaining carbocyclic quaternary α-nitroamides as chiral building blocks.