Association between serum gamma-glutamyltransferase and C-reactive protein
Association between serum gamma-glutamyltransferase and C-reactive protein
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DOI：
10.1016/j.atherosclerosis.2004.08.027
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发表时间：
2005-02-01
期刊：
影响因子：
5.3
通讯作者：
Jacobs, DR
中科院分区：
文献类型：
--
作者：
Lee, DH;Jacobs, DR
一系列流行病学研究表明，正常范围内的血清γ谷氨酰转移酶（GGT）可能是氧化应激的早期标志。氧化应激似乎是与慢性炎症相关的许多反应的关键组成部分。因此，我们在第三次美国国家健康和营养检查调查的 12,110 名成年参与者中检查了血清 GGT 十分之一与血清 C 反应蛋白 (CRP)（慢性炎症标志物）浓度之间的横断面关联。调整种族、性别、年龄、吸烟、饮酒和体重指数 (BMI) 后，所有十分位的 GGT 血清浓度与 CRP 血清浓度呈正相关（趋势 P < 0.01）。例如，按血清 GGT 十分之一计算的血清 CRP 大于或等于 3.0 mg/L 的调整后相对风险为 1.0、1.23、1.40、1.59、1.62、1.61、2.17、2.38、2.45 和 3.41（趋势 P < 0.01）。在所有亚组中都一致观察到这种关联；非西班牙裔白人、非西班牙裔黑人、墨西哥裔美国人、男性、女性、非饮酒者、饮酒者、非吸烟者、戒烟者、当前吸烟者、BMI < 25、BMI 25-29.9 和 BMI 大于或等于 30。血清 GGT 和 CRP 的强相关性表明，对细胞和/或血清 GGT 的进一步研究可能有助于阐明氧化应激与炎症之间的关联。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
A series of epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation. Therefore, we examined the cross-sectional association between deciles of serum GGT and concentrations of serum C-reactive protein (CRP), a marker of chronic inflammation, among 12,110 adult participants in the third U.S. National Health and Nutrition Examination Survey. After adjustment for race, sex, age, cigarette smoking, alcohol intake, and body mass index (BMI), serum concentration of GGT across all deciles was positively associated with serum concentrations of CRP (P for trend < 0.01). For example, adjusted relative risks of serum CRP greater than or equal to 3.0 mg/L by deciles of serum GGT were 1.0, 1.23, 1.40, 1.59, 1.62, 1.61, 2.17, 2.38, 2.45, and 3.41 (P for trend < 0.01). This association was consistently observed among all subgroups; Non-Hispanic White, Non-Hispanic Black, Mexican American, men, women, non-drinkers, drinkers, non-smokers, ex-smokers, current smokers, BMI < 25, BMI 25-29.9, and BMI greater than or equal to 30. The strong association of serum GGT and CRP suggest that further studies on cellular and/or serum GGT might help to elucidate the association between oxidative stress and inflammation. (C) 2004 Elsevier Ireland Ltd. All rights reserved.