Where hearing starts: the development of the mammalian cochlea.
Where hearing starts: the development of the mammalian cochlea.
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DOI：
10.1111/joa.12314
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发表时间：
2016-02
影响因子：
2.4
通讯作者：
Groves AK
中科院分区：
文献类型：
--
作者：
Basch ML;Brown RM 2nd;Jen HI;Groves AK
哺乳动物的耳蜗是一种非凡的感觉器官，能够感知 1012 压力范围内的声音，并区分不同物种的次声波和超声波频率。哺乳动物耳蜗的感觉毛细胞非常敏感，能够以数十微秒的速度对原子级的偏转做出反应。毛细胞的数量和位置是在内耳发育过程中精确确定的，大量的发育过程沿着耳蜗管的长度塑造这些细胞的形状、大小和形态，使它们对不同的声音频率做出最佳的反应。在这篇综述中，我们简要讨论了哺乳动物耳蜗的进化起源，然后描述了导致其诱导、细胞周期退出、细胞模式以及沿其长度建立拓扑不同频率响应的连续发育过程。
The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a range of 1012 in pressure and discriminating both infrasonic and ultrasonic frequencies in different species. The sensory hair cells of the mammalian cochlea are exquisitely sensitive, responding to atomic-level deflections at speeds on the order of tens of microseconds. The number and placement of hair cells are precisely determined during inner ear development, and a large number of developmental processes sculpt the shape, size and morphology of these cells along the length of the cochlear duct to make them optimally responsive to different sound frequencies. In this review, we briefly discuss the evolutionary origins of the mammalian cochlea, and then describe the successive developmental processes that lead to its induction, cell cycle exit, cellular patterning and the establishment of topologically distinct frequency responses along its length.