Multidrug chemotherapy using bleomycin, methotrexate, and cisplatin alone or combined with radiotherapy in advanced head and neck cancer.
Multidrug chemotherapy using bleomycin, methotrexate, and cisplatin alone or combined with radiotherapy in advanced head and neck cancer.
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单独使用博莱霉素、甲氨蝶呤和顺铂的多药化疗或联合放疗治疗晚期头颈癌。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
E. Robinson
中科院分区：
文献类型：
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作者：
A. Kuten;J. Zidan;Y. Cohen;E. Robinson
22例晚期头颈癌患者接受博莱霉素、甲氨蝶呤和顺铂联合治疗。在10例既往未接受治疗的患者中，观察到完全缓解（CR）率为20%，部分缓解率为50%，无变化率为30%。随着放射治疗的增加，该组患者的局部CR率增加到60%。术后复发12例，CR率25%，部分缓解率16.7%，无变化率58.3%。毒性作用可接受，无死亡。这些短期结果鼓励更多的患者参与研究，并进一步随访，以确定是否可以通过使用顺铂和放疗来提高晚期未经治疗的头颈癌患者的治愈率。对于放疗后复发的患者应进行更积极的治疗。
Twenty-two patients with advanced cancer of the head and neck where treated with a combination of bleomycin, methotrexate, and cisplatin. In ten previously untreated patients, a complete response (CR) rate of 20%, a partial response rate of 50%, and a no change rate of 30% were observed. With the addition of radiotherapy, the local CR rate in this group of patients increased to 60%. In 12 patients with recurrent disease after surgery and/or radiotherapy, the CR rate was 25%, the partial response rate was 16.7%, and the no change rate was 58.3%. Toxic effects were acceptable, with no fatalities. These short-term results encourage accrual of more patients in the study and further follow-up to determine whether the cure rate can be increased by using cisplatin and radiotherapy in patients with advanced previously untreated head and neck cancer. More energetic treatment should be investigated in patients having disease recurrence after radiotherapy.