Towards clinical trials of lie detection with fMRI
Towards clinical trials of lie detection with fMRI
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DOI：
10.1080/17470910802188370
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发表时间：
2009-01-01
影响因子：
2
通讯作者：
Langleben, D. D.
中科院分区：
文献类型：
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作者：
Hakun, J. G.;Ruparel, K.;Langleben, D. D.
最近关于基于功能磁共振成像技术在单个受试者中成功区分谎言和真相的报道引起了潜在用户的兴趣以及公众对该技术潜在范围的担忧。越来越多的审查凸显了缺乏受控的口服寿命，即该技术符合医疗器械开发通用标准的前瞻性临床试验。鉴于基于功能磁共振成像的测谎数据缺乏，进行此类试验的道德也受到质疑。为了探讨将实验室研究转化为实践的潜在问题，我们进行了一项案例研究，其中我们将标准犯罪知识测试（GKT）（一种行之有效的产生欺骗的模型）应用于简历上撒谎的常见场景。该任务包括有关受试者简历上相关项目的问题，其中三个可以独立验证为真实性（已知），三个无法验证，因此被称为未知。对象有动机对所有未知项目撒谎，并且在汇报中证实他已经这样做了。数据经过预处理，用先验感兴趣区域掩盖，阈值化，并定性评估与先前报道的前额顶叶谎言真相模式的一致性。对三个未知项目中的两个的欺骗性反应与预测的前额顶叶功能磁共振成像模式相关。在第三个“未知”中，这种模式不存在，相反，观察到边缘系统（杏仁核和海马体）反应增加。根据已发表的前额顶叶谎言反应模式，只有前两项可以归类为谎言。如果得到证实，这种在谎言真相对比中杏仁核和海马体激活的表现说明需要将边缘系统及其情感和认知相关性整合到现有的欺骗模型中。我们的实验提出了一种自然场景的方法和需要回答的研究问题，以便为基于功能磁共振成像的测谎的前瞻性临床试验奠定基础。
Recent reports of successful fMRI-based discrimination between lie and truth in single subjects raised the interest of prospective users and a public concern about the potential scope of this technology. The increased scrutiny highlighted the lack of controlled oreal lifeo, i.e. prospective clinical trials of this technology that conform to the common standards of medical device development. The ethics of conducting such trials given the paucity of data on fMRI-based lie detection has also been questioned. To probe the potential issues of translating the laboratory research into practice, we conducted a case study in which we adapted the standard Guilty Knowledge Test (GKT), a well-established model of producing deception, to the common scenario of lying on a resume. The task consisted of questions about pertinent items on the subject's resume, three of which could be independently verified as truth (KNOWN) and three that could not be verified and were thus termed UNKNOWN. The subject had an incentive to lie on all UNKNOWN items, and on debriefing confirmed that he had done so. Data was preprocessed, masked with a priori regions of interest, thresholded, and qualitatively evaluated for consistency with the previously reported prefronto-parietal Lie Truth pattern. Deceptive responses to two out of the three UNKNOWN items were associated with the predicted prefronto-parietal fMRI pattern. In the third UNKNOWN this pattern was absent, and instead, increased limbic (amygdala and hippocampus) response was observed. Based on published prefronto-parietal Lie response pattern, only the first two items could be categorized as Lie. If confirmed, this demonstration of amygdala and hippocampus activation in a Lie Truth contrast illustrates the need to integrate the limbic system and its emotional and cognitive correlates into the existing model of deception. Our experiment suggests an approach to a naturalistic scenario and the research questions that need to be answered in order to set the stage for prospective clinical trials of fMRI-based lie detection.