Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes
Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes
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DOI：
10.1038/386259a0
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发表时间：
1997-03-20
期刊：
影响因子：
64.8
通讯作者：
Radford, SE
中科院分区：
文献类型：
--
作者：
Aggeli, A;Bell, M;Radford, SE
分子自组装正成为一种越来越受欢迎的新的超分子结构和分子材料的途径（1-7）。这种结构的灵感通常来自生物学中的自组装系统。在这里，我们表明，一个生物基序，肽β-片，可以利用设计的寡肽，自组装成聚合物磁带和潜在有用的机械性能。我们描述了寡肽的构建，合理设计或基于天然蛋白质的片段，其在合适的溶剂中聚集成长的半柔性β-折叠带。这些甚至在低体积分数下也变得缠结以形成凝胶，其粘弹性可以通过化学（pH）或物理（剪切）影响来控制。我们建议，它应该是可能的工程师在这些凝胶中的广泛的性质，通过适当选择的肽的一级结构。
Molecular self-assembly is becoming an increasingly popular route to new supramolecular structures and molecular materials(1-7). The inspiration for such structures is commonly derived from self-assembling systems in biology. Here we show that a biological motif, the peptide beta-sheet, can be exploited in designed oligopeptides that self-assemble into polymeric tapes and with potentially useful mechanical properties. We describe the construction of oligopeptides, rationally designed or based on segments of native proteins, that aggregate in suitable solvents into long, semi-flexible beta-sheet tapes. These become entangled even at low volume fractions to form gels whose viscoelastic properties can be controlled by chemical (pH) or physical (shear) influences. We suggest that it should be possible to engineer a wide range of properties in these gels by appropriate choice of the peptide primary structure.