Molecular insights and therapeutic targets for diabetic endothelial dysfunction.
Molecular insights and therapeutic targets for diabetic endothelial dysfunction.
复制标题
DOI：
10.1161/circulationaha.108.835223
复制
发表时间：
2009-09-29
期刊：
影响因子：
37.8
通讯作者：
Zou MH
中科院分区：
文献类型：
--
作者：
Xu J;Zou MH
内皮在血管疾病中的作用使得临床测试的发展能够评估正常和活化内皮的功能特性。 5 理想情况下，此类测试应安全、无创、可重复、廉价且在实验室之间标准化。结果还应反映动脉粥样硬化疾病整个自然史中内皮的动态生物学，定义亚临床疾病过程，并为后期临床阶段的风险分层提供预后信息。 6 目前没有任何一项测试能够满足这些要求，因此需要使用多项测试来表征内皮生物学的多个方面。由于人类的内皮功能无法直接测量，因此可以通过测量内皮依赖性血管舒张（血管调节）、内皮衍生调节蛋白（NO、内皮衍生超极化因子、前列环素 [PGI2]、TXA2 和内皮素-1 [ET-1]）血浆水平以及可能的微量白蛋白尿来间接获得估计值。可以测量的内皮功能的其他方面是凝血、纤维蛋白溶解、炎症和血管生成。 7 其他血管特性，例如颈动脉的动脉硬度和内膜/中膜厚度，可能仅部分依赖于内皮。 8
endothelium in vascular disease has enabled the development of clinical tests to evaluate the functional properties of normal and activated endothelium. 5 Ideally, such tests should be safe, noninvasive, reproducible, inexpensive, and standardized between laboratories. The results should also reflect the dynamic biology of the endothelium throughout the natural history of atherosclerotic disease, define subclinical disease processes, and provide prognostic information for risk stratification in the later clinical phase. 6 No single test currently fulfills these requirements, which necessitates the use of several tests to characterize the multiple aspects of endothelial biology. Because endothelial function cannot be measured directly in humans, estimates may be obtained indirectly by measuring the endothelium-dependent vasodilation (vasoregulation), plasma levels of endothelium-derived regulatory proteins (NO, endothelium-derived hyperpolarizing factor, prostacyclin [PGI2], TXA2, and endothelin-1 [ET-1]), and possibly microalbuminuria. Additional aspects of endothelial function that can be measured are coagulation, fibrinolysis, inflammation, and angiogenesis. 7 Other vascular properties such as arterial stiffness and intima/media thickness of the carotid artery are likely only endothelium dependent in part. 8