Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants
Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants
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DOI：
10.1016/s0140-6736(97)04229-3
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发表时间：
1997-09-20
期刊：
影响因子：
168.9
通讯作者：
Alonso, PL
中科院分区：
文献类型：
--
作者：
Menendez, C;Kahigwa, E;Alonso, PL
背景疟疾和贫血，尤其是缺铁性贫血，是世界范围内发病率最高的两种疾病。关于恶性疟原虫感染和缺铁对疟疾流行地区贫血病因学的相对贡献，人们知之甚少。方法将1995年1月至10月在坦桑尼亚疟疾高发区一家医院出生的832名婴儿随机分为DI组、IP组、DP组和PP组，分别每日口服铁剂(每天2 mg/kg)和每周服用替他普林(3.125 mg乙胺嘧啶+25 mg氨苯松钠)；8~24周龄每日补充，8~48周龄每周化学预防。严重贫血的频率(红细胞压积
Background Malaria and anaemia, especially that due to iron deficiency, are two leading causes of morbidity worldwide. Little is known about the relative contribution of Plasmodium falciparum infection and iron deficiency to the aetiology of anaemia in malaria-endemic areas. We undertook a randomised comparison of different strategies for control of anaemia and malaria in infants, including an assessment of the effect of iron supplementation on malaria susceptibility.Methods 832 infants born at one hospital in a malaria-hyperendemic area of Tanzania between January and October, 1995, were randomly assigned to group DI, receiving daily oral iron (2 mg/kg daily) plus weekly Deltaprim (3.125 mg pyrimethamine plus 25 mg dapsone); group IP, receiving iron plus weekly placebo; group DP, receiving daily placebo plus weekly Deltaprim; or group PP, receiving daily placebo plus weekly placebo. Daily supplementation was given from 8 to 24 weeks of age, and the weekly chemoprophylaxis from 8 to 48 weeks. The frequency of severe anaemia (packed-cell volume